Evaluation of changes in levels of plasma MDA and antioxidant  vitamin E in Sudanese patients with diabetes type II

Elrasheed I. Mohamed; Badr Eldien H.  Elabid; Altayeb  Elazomi; Hana  Fahelbum; Hakem  Zwaik; Nazeha   Mansuri; Salah  Bahroun

doi:10.54361/

Authors

Elrasheed I. Mohamed Faculty of Medical Technology, Zawia University Author
Badr Eldien H. Elabid University of Science and Technology, Sudan Author
Altayeb Elazomi Faculty of Medical Technology, Zawia University Author
Hana Fahelbum Faculty of Medical Technology, Zawia University Author
Hakem Zwaik Faculty of Sciences Zawia University Author
Nazeha Mansuri National Medical Research Centre, Zawia, Libya Author
Salah Bahroun National Medical Research Centre, Zawia, Libya Author

DOI:

https://doi.org/10.54361/

Keywords:

Diabetes mellitus, vitamin E, MDA, Libya

Abstract

Free radicals have important roles in pathogenesis of diabetes mellitus. It has been well documented that there is a link between oxidative stress and secondary complications of diabetes. In the present study we determined and evaluated changes in levels of malondialdehyde (MDA) and antioxidant vitamin E in plasma of Sudanese patients with Type II diabetes mellitus. Total of 200 diabetic patients (90 males, 110 females) with mean age of 55.48 ± 12.14 years were recruited into the study. Control group was composed of 100 healthy volunteers (47 males, 53 females) with mean age of 53.53 ± 11.43 years. In addition to the two mentioned parameters, levels of fasting blood glucose and percentages of HbA1C levels were determined in diabetic patients and controls. There was a significant increase in the MDA level (test group) which is used as an indicator of metabolic stress, oxidative stress or lipid per oxidation marker. On the other hand; antioxidant vitamin E of the test group was reduced meaningfully. Reduction in vitamin E levels was probable due to antioxidant effect of this antioxidant vitamin. In conclusion, supplementation of antioxidant vitamins into the daily diets of diabetic patients will enhance power of non-enzymatic antioxidant defense systems.

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