Effect of supplementary folic acidintake for pregnant women on the newborn birthweight

Authors

  • Abdalla A. Mohamed Medical Nutrition Department, Faculty of Medical Technology, university of Zawia Author
  • Taher Abd elhameed Medical Nutrition Department, Faculty of Medical Technology, university of Zawia. Author
  • Wayel Almrabet Medical Laboratory Department, Faculty of Medical Technology, university of Zawia Author
  • Altayeb Elazomi Medical Laboratory Department, Faculty of Medical Technology, university of Zawia. Author
  • Elhadi Araibi Medical Laboratory Department, Faculty of Medical Technology, university of Zawia. Author
  • Fawzia Shawesh Medical Laboratory Department, Faculty of Medical Technology, university of Zawia. Author
  • Nada alzubadi Diagnostic and Radiology Department, Faculty of Medical Technology, university of Zawia Author
  • Salah Bahroun National Medical Research Center, Zawia Libya. Author
  • Khaled Aburass National Medical Research Center, Zawia, Libya. Author
  • Abd elkarim Abdalla Nursing Department, Faculty of Medical Technology, university of Zawia Author

DOI:

https://doi.org/10.54361/ljmr15.1.04

Keywords:

Folic acid, pregnant woman, birthweight

Abstract

  Back ground During pregnancy the woman needs a good nutritional status for a healthy outcome. Poor nutritional statuses cause higher risks of malnutritional diseases and deaths for women and their embryos. Folic acid deficiency negatively affects pregnancy outcomes due to its association with DNA synthesis, and since the folic acid intake during pregnancy plays a significant role in modulating gene expression, the dose and its timing during pregnancy may be critical. This study The study was designed to investigate the effect of folic acid on pregnancy. A total of 92 pregnant women participated in this study. These pregnant women were classified into 3 groups according to their ages (20 – 30 years, 31 – 41years, and above 40years). The three groups were examined through a questionnaire that has to be answered by the pregnant women themselves. Result  The majority of woman were among the first age group (20- 30 years), whereas the highest percentage of diabetic women were in the last group (above 41 years). Birthweights were higher if the woman who took folic acid during pregnancy especially if they were diabetic. In fact, diabetic women that did not take folic acid during pregnancy had the lowest birthweights compared to all other groups.  Conclusion  The data suggested that taking folic acid supplementation helps in developing the fetus and thus the newborn baby will have a normal birthweight. Diabetic women showed that the average birthweights of their newborn babies were higher than the normal when they took folic acid and lower than normal in the absence of the supplementary folic acid.   

   

   

   

   

References

Nutrition of women in the preconception period, during pregnancy and the breastfeeding period (WHO-2012)

Salvador Villalpando. Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development. 2008. Food and Nutrition Bulletin, vol. 29, no. 2 DOI: https://doi.org/10.1177/15648265080292S115

Wallingford JB, Niswander LA, Shaw GM, Finnell RH: The continuing challenge of understanding, preventing, and treating neural tube defects. Science 2013, 339:1222002. DOI: https://doi.org/10.1126/science.1222002

SubitBarua*, Salomon Kuizon and Mohammed A Junaid. Folic acid supplementation in pregnancy and implications in health and disease. Journal of Biomedical Science 2014, 21:77 DOI: https://doi.org/10.1186/s12929-014-0077-z

Pitkin RM: Folate and neural tube defects. Am J ClinNutr 2007, 85:285S–288S. DOI: https://doi.org/10.1093/ajcn/85.1.285S

Callender STE: A critical review of pernicious anaemia of pregnancy. Q J Med 1944, 13:75– 105.

Rosati R, Ma H, Cabelof DC: Folate and colorectal cancer in rodents: a model of DNA repair deficiency. J Oncol 2012:105949. DOI: https://doi.org/10.1155/2012/105949

De Regil LM, Fernandez-Gaxiola AC, Dowswell T, Pena-Rosas JP: Effects and safety of periconceptional folate supplementation for preventing birth defects. Cochrane Database Syst Rev 2010, CD007950. DOI: https://doi.org/10.1002/14651858.CD007950.pub2

Milunsky A, Jick H, Jick SS, et al. Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. JAMA. 1989 Nov 24;262(20):2847-52. PMID: 2478730. DOI: https://doi.org/10.1001/jama.262.20.2847

Moore LL, Bradlee ML, Singer MR, et al. Folate intake and the risk of neural tube defects: an estimation of dose-response. Epidemiology. 2003 Mar;14(2):200-5. PMID: 12606886. 9 DOI: https://doi.org/10.1097/01.EDE.0000040253.12446.B2

Centers for Disease Control and Prevention (CDC). CDC Grand Rounds: additional opportunities to prevent neural tube defects with folic acid fortification. MMWR Morb Mortal Wkly Rep. 2010 Aug 13;59(31):980-4. PMID: 20703205

Stoltenberg C. Effects of periconceptional folate on language delay and autism spectrum disorders: The Norwegian mother and child cohort study. Neuropsychopharmacology. 2013;38:S38.

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Published

30-06-2021

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How to Cite

1.
Mohamed AA, Abde lhameed T, Almrabet W, Elazomi A, Araibi E, Shawesh F, et al. Effect of supplementary folic acidintake for pregnant women on the newborn birthweight. LJMR [Internet]. 2021 Jun. 30 [cited 2024 Nov. 21];15(1):40-8. Available from: https://ljmr.ly/index.php/ljmr/article/view/171