Analgesic effect by using hot Plat and tail flick test in rats models for aqueuos moringa oleifer extract

Abstract

Introduction Drugs and plants are closely related to each other through the use of traditional medicines that is mainly prepared from plants. Plants are screened for presence of bioactive components responsible for the activity. Various types of plants have been used not only as dietary supplements but also as traditional treatments for many diseases. Moringaoleifera of  Moringaceae is a potential source of phytochemical ingredients claimed to have analgesic property. Objective The present study aimed to investigate the analgesic activity of Moringaoleifera extract in albino rats by using taıl flıck and hot plat test. Methods: Leaves of Moringaoleifera were collected April 2022 from Surman (Libya). And then the powder was macerated in 1 L of distilled water for 3 days and evaporated to dryness by rotary evaporator. The crude extract was administered by oral gavaging in doses (50mg/kg_100mg/kg). The study was done by using experimental models, the albino rats were divided into 4 groups, each group consisting of 3 rats. Group I: Control (dH2O given orally at 2 ml/kg); Group II: Standard (100 mg/kg of Panadol orally.); Group III, IV, (MOE 50, 100 mg/kg, respectively), the analgesic effect was evaluated by using taıl flıck and hot plat test, through the reaction time was recorded  in various time intervals) 60, 90, and 120 minutes). Results: MOE significantly a high significant increase in latency response (P<0.001) in comparison to control and standrad. Conclusion: These results indicate the ability of MOE to inhibit thermally induced nociceptive processes, which is a characteristic of strong analgesics