Abnormal Serum Concentrations of Creatinine, Phosphorous, Triglycerides and  Total Cholesterol in Males with End-Stage Renal Disease: A Comparative Study

Abdounasser Albasher Omar; Nada  Salem; Sundus  Sagar; Aisha  Hamid; Hajer  Diab; Maryam Mohammed  Alnnas

doi:10.54361/

Authors

Abdounasser Albasher Omar Department of Chemistry, Gharyan’s Faculty of Science, Gharyan University, Gharyan, Libya. Author
Nada Salem Undergraduate student, Department of Chemistry, Gharyan’s Faculty of Science, Gharyan University, Gharyan, Libya. Author
Sundus Sagar Undergraduate student, Department of Chemistry, Gharyan’s Faculty of Science, Gharyan University, Gharyan, Libya. Author
Aisha Hamid Undergraduate student, Department of Chemistry, Gharyan’s Faculty of Science, Gharyan University, Gharyan, Libya. Author
Hajer Diab Undergraduate student, Department of Chemistry, Gharyan’s Faculty of Science, Gharyan University, Gharyan, Libya. Author
Maryam Mohammed Alnnas Department of Chemistry, Gharyan’s Faculty of Science, Gharyan University, Gharyan, Libya. Author

DOI:

https://doi.org/10.54361/

Keywords:

ESRD, creatinine, phosphorous, triglycerides, total cholesterol, t-test; correlation

Abstract

This study investigated the concentration abnormalities of serum creatinine (SCr), serum phosphorous (SP), serum triglycerides (STg) and serum total Cholesterol (STc) in males suffering from End-StageRenal Disease (ESRD). The serum concentration of each biochemical was determined in 30 males with ESRD (patient group) and in 30 normal males (control group). Except for STc, the mean concentration for all the biochemicals in the patient group was higher than the mean of the equivalent biochemical in the control group. However, the difference was only significant in case of SCr pair and SP pair (P < 0.01). Two significant relationships (P < 0.05) were found in patient group between two pairs: SCr-SP and STg-STc. These two relationships were not recorded in the control group. Similarly, the only significant relationship between age and SCr (P < 0.05) found in the control group was not recorded in the patient group. These limited differences in relationships were accompanied by limited differences in similarity ratio according to the results of cluster analysis. The findings of this study indicate that ESRD has a diverse effect on serum concentration of the studied biochemicals, with more prominent impact on SCr and SP. According to the results of statistical analysis, SP can be used in combination with SCr for early identification of ESRD.

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