The anti-hyperglycemic and the anti-hyperlipidemia effects of Cynara Cornigera heads alcoholic extract on Alloxan-induced diabetes in Rat.
DOI:
https://doi.org/10.54361/LJMR.16-1-2B-03Keywords:
Cynara Cornigera, hypoglycemia, AlloxanAbstract
Background: Cynara Cornigera (CC), family Asteraceae, is locally known as Gaamool. It is widely distributed in the northeastern part of Libya. CC heads and leaves are used in folk medicine for various illnesses such as diabetes, hepatic dysfunction, hyperlipidemia, and dyspeptic disorders. Aim: This study aims to investigate the hypoglycemic and hyperlipidemia effects of CC-heads alcoholic extract in normal and Alloxan-induced diabetes in rats.
Methods: The acute hypoglycemic effect of 30% W/V CC was tested against the glucose tolerance test (GTT). In addition, the sub-acute (once a day for a week) effect of 15% W/V CC extract was studied in normoglycemic rats. In the Alloxan model, hyperglycemia was induced by a single 120 mg/kg intraperitoneal injection (IP), and then the acute and sub-acute effects of CC were tested. Blood glucose levels have been determined by diabetes test strips (on-call plus glucometer). Glucose and ketones in urine were also measured by using deep sticks. Blood has been collected by cardiac puncture for further study to determine triglycerides, cholesterol, and liver enzymes (AST and ALT).
Result: The administration of 30% W/V CC showed a significant decrease in glucose levels in the GTT. Furthermore, in Alloxan-induced rats, CC extract resulted in a significant decrease (P 0.001) in glucose levels after a single dose (30% W/V); furthermore, it reduced blood glucose levels (P 0.05) after a week of daily administration of a single dose of (15% W/V). Moreover, the CC decreased the concentrations of glucose and ketones in urine that had been produced as a result of Alloxan hyperglycemia. Blood cholesterol, triglyceride, and liver enzyme (AST-ALT) levels that had been raised by Alloxan were reversed by CC extract.
Conclusion: The study revealed that the CC-head extract may contain compounds that possess hypoglycemic and hypolipidemic properties.
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