Lung Function Parameters in Healthy Libyan Children and Adolescents aged between 4 - 19 years

Authors

  • Faraj Abdussalam Pediatric Department, Tripoli Medical Center, University of Tripoli, Libya. Author
  • Adel Gritli Pediatric Department, Tajoura Hospital, Libya. Author
  • Millad Ghawil Pediatric Department, Tripoli Medical Center, University of Tripoli, Libya, Author
  • Suad Elmeddah Pediatric Department, Tripoli Medical Center, University of Tripoli, Libya, Author
  • Ali Mgadmi Pediatric Department, Tripoli Medical Center, University of Tripoli, Libya, Author
  • Alois Zapletal Department of Pediatrics, University Hospital of Motol, Prague, Czech Republic Author

DOI:

https://doi.org/10.54361/

Keywords:

lung function tests, Expiratory flow-volume curves

Abstract

Background: No appropriate reference values of lung function parameters exist in healthy Libyan children with which the same parameters of pediatric respiratory patients of this country can be compared. Our aim; to asses lung function parameters in Libyan healthy children to use in assessment of lung function abnormalities in children with respiratory disease. Methods: Spirometeric values were measured in a group of 449 healthy Libyan children and adolescents (226 boys and 223 girls), aged between 4-19 years old. Multiple linear analysis was performed for each spirometric parameter against age, weight, height and BMI.  Results: The values of the measured parameters increased nonlinearly and correlated significantly with body height (P 0.05); the correlation was much lower with age. The best- fit regression equation relating the measured parameters values and body height was a simple power function providing the possibility to calculate the mean value with lower and upper limits for each parameter. No statistical significant differences of the studied functional parameters were found between boys and girls.  Conclusions: our reference values are close to those of the European children. These developed predictive values can be used in clinical practice in Libya and in other neighboring North African countries. 

References

American Thoracic Society. Lung function testing: selection of reference values and interpretative strategies. Am Rev Respir Dis. 1991; 144: 1202–1218

Cotes JE. Lung Function. Assessment and Application in Medicine. Blackwell Scientific Publications, Oxford, 4th Ed. 1979.

Dufetel P, Wazni A, Gaultier C, Derossi G, Cisse F, Martineaud JP. Growth and ventilatory function in Black children and adolescents. Rev Mal Respir 1995; 12: 135- 143.

McKenzie SA, Chan E, Dundas I, Bridge PD, Pao CS, Mylonopoulu M, Healy MJ. Airway resistance measured by the interrupter technique: normative data from 2-10 year olds of three ethnicities. Arch Dis Child 2002; 87:248-251.

Ip MS, Karlberg EM, Karlberg JP, Luk KD, Leong JC. Lung function reference values in Chinese children and adolescents in Hong Kong. I. Spirometric values and comparisons with other populations. Am J Respir Crit Care Med 2000; 162:424-429.

Harik-Khan RI, Muller DC, Wise RA. Racial difference in lung function in African- American and White children: effects of anthropometric, socioeconomic, nutritional, and environmental factors. Am J Epidemiol 2004; 160: 893-900.

Rosenthal M, Bain SH, Cramer D, Helms P, Denison P, Bush A, Warner JO. Lung function in white children aged 4 to 19 years: I-Spirometry. Thorax 1993; 48: 794-802.

Wang X, Dockery DW, Wypij D, Fay ME, Ferris BG Jr. Pulmonary function between 6 and 18 years of age. Pediatr Pulmonol 1993; 15: 75-88.

Stocks J, Gappa M, Rabbette PS, Hoo AF, Mukhtar Z, Costeloe KL. A comparison of respiratory function in Afro-Caribbean and Caucasian infants. Eur Respir J 1994; 7: 11- 16.

Sylvester KP, Milligan P, Patey RA, Rafferty GF, Greenough A. Lung volumes in healthy Afro-Caribbean children aged 4-17 years. Pediatr Pulmonol 2005; 40: 109-112.

Trabelsi Y, Ben Saad H, Tabka Z, Gharbi N, Bouchez Buvry A, Richalet JP, Guenard H. Spirometric reference values in Tunisian children. Respiration 2004; 71: 511-518.

Al-Riyami BM, Al-Rawas OA, Hassan MO. Normal spirometric reference values for Omani children and adolescents. Respirology 2004; 9: 387-391.

Graff-Lonnevig V, Harfi H, Tipirneni P. Peak expiratory flow rates in healthy Saudi Arabian children living in Riyadth. Ann Allergy 1993; 71: 446-450.

Al- Dawood K. Peak expiratory flow rate in Saudi schoolboys at Al-Khobar City, Saudi Arabia. Saudi Med J 2000; 21: 561-564.

Lawlor, D.A., Ebrahim, S., and Davey Smith, G. Association between self-reported childhood socioeconomic position and adult lung function: findings from the British Women's Heart and Health study. Thorax. 2004; 59: 199–203

American Thoracic Society. Lung function testing: selection of reference values and interpretative strategies. Amer Rev Respir Dis 1991; 144: 1202-1218.

Shamssain MH, Thompson J, Ogston SA. Forced expiratory indices in normal Libyan children aged 6-19 years. Thorax 1988; 43: 467-470.

Zapletal A, Chalupová J. Forced expiratory parameters in healthy preschool children (3- 6 years of age). Pediatr Pulmonol 2003; 35: 200-207.

Zapletal A, Šamánek M, Paul T. Lung function in children and adolescents. Methods, reference values. Prog Respir Res 1987; 22: 1-220.

Zapletal A, Rydlová J, Hak J. Dry powder long acting bronchodilators in asthmatic children and adolescents. Alergie 2002; 4: 285-290.

Zapletal A, Motoyama EK, van de Woestijne KP Hunt VR, Bouhuys A. Maximum expiratory flow-volume curves and airway conductance in children and adolescents. J Appl Physiol 1969; 26: 308-316.

Zapletal A, Šamánek M, Paul T. Upstream and total airway conductance in children and adolescents. Bull Eur Physio-Path Resp 1982; 18: 31-37.

Downloads

Published

30-06-2018

Issue

Section

Articles

How to Cite

1.
Abdussalam F, Gritli A, Ghawil M, Elmeddah S, Mgadmi A, Zapletal A. Lung Function Parameters in Healthy Libyan Children and Adolescents aged between 4 - 19 years . LJMR [Internet]. 2018 Jun. 30 [cited 2024 Nov. 25];12(1):82-95. Available from: https://ljmr.ly/index.php/ljmr/article/view/239