Effects of Virgin Olive Oil on Renal Function and Histopathological Alterations in Hyperlipidemic Rats
DOI:
https://doi.org/10.54361/LJMR.20.2.61Keywords:
Virgin olive oil, hyperlipidemia, Kidney injury, histopathology, ratsAbstract
Background: hyperlipidemias represent one of the possible factors which contribute to the aetiology, pathogenesis and establishment of renal diseases. In our present work, we are targeting to study the effect of the administration of Virgin Olive Oil at low and high doses on kidney function and histopathology in hyperlipidaemic male albino rats. Material & Methods: Male albino rats were grouped into a normal and hyperlipidemic diet, and some hyperlipidemic groups were treated with the addition of virgin olive oil at (LOW and HIGH doses). Serum kidney parameters were measured to evaluate kidney functionality. Kidneys were then excised, processed and examined for histology by staining with Hematoxylin and Eosin (H&E). Results: In hyperlipidemic treated animals (LOW and HIGH doses), the levels of urea concentration were significantly reduced in the two groups as compared to the other two groups (hyperlipidemic without treatment and normolipidemic). No significant differences were observed for serum creatinine levels between any of the experimental groups. Light microscopic examination of the kidneys revealed evident restoration of the kidney tissue lesions that were present in the hyperlipidemic without treatment groups, and a greater recovery effect was reported in the high dose of olive oil, with kidney tissues close to the normalised kidney tissues. Conclusion: virgin olive oil, at both doses (LOW and HIGH), protects against kidney injury resulting from hyperlipidemias in male albino rats. It improves renal tissue histopathology and lowers serum urea concentration in conditions of hyperlipidemias.
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