EFFECTS OF  NIGELLASATIVA AND ALLIUM  SATIVUM ON TYPE 1 DIABETES

Taher M. Abd elhameed; Fatma  Alashkham; Afaf  Hmza; Muhamed T.  Osman

doi:10.54361/ljmr15.1.02

Authors

Taher M. Abdelhameed Department of medical nutrition , Faculty of Medical Technologies , Zawia University Author
Fatma Alashkham Department of Anesthesia and intensive care , Faculty of Medical Technologies , Zawia University Author
Afaf Hmza Department of Anesthesia and intensive care , Faculty of Medical Technologies , Zawia University Author
Muhamed T. Osman Department of Pathology, Faculty of Medicine &Defence Health, University of Malaysia Author

DOI:

https://doi.org/10.54361/ljmr15.1.02

Keywords:

Nigella sativa, Allium sativum, diabetes, STZ, FBG, Insulin

Abstract

Allium sativum (Garlic) and Nigella sativa (Black cumin) are widely used as food seasoning or traditional medications in many countries. Their effects on STZ induced type 1 diabetes in rats were compared.Type 1 diabetes induced to rats by injecting STZ. The oil extracts of A. sativum and N. sativa were peritoneally injected daily at concentrations of 10 mg/kg, 20 mg/kg for A. sativum and 7 mg/kg or 14 mg/kg for N. sativa. Compared to the untreated group, the two groups treated with A. sativum and the two groups treated with N. sativa showed marked recoveries in some physiological aspects. The data showed marked improvements in body weights for all treated groups especially the groups treated with A. sativum, and after four weeks body weights were improving whereas body weights for untreated group were decreased. FBG levels in the group treated with 10mg/kg A. sativum showed the best improvement, but by the end of the month all treated groups FBG levels were less than half of the blood glucose levels for untreated group but still about twice of that in the normal animals in the control group. Blood insulin levels in the group treated with 20 mg/kg A. sativum was 81% of the control, but all the other groups were also higher than that of the untreated group. In fact, A. sativum showed better results compared to N. sativa but both plants showed improving of the conditions of type 1 diabetes.

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