Evaluation the efficacy of three brands of Ceftriaxone against various strains of bacteria by measuring zone of inhibition

Authors

  • Ibrahim Egfair Faculty of Pharmacy, Alasmarya Islamic University, Libya Author
  • Ryad M. O. Alati Faculty of Pharmacy, Alasmarya Islamic University, Libya Author
  • Abdullah M. O. Bakoosh Faculty of Medicine, Alasmarya Islamic University, Libya Author
  • AbuAjeela M. Alfalos Faculty of Medicine, Alasmarya Islamic University, Libya Author
  • Mahmoud A. L. Ruaua Biotechnology Research Centre, Tripoli, Libya Author
  • Ashraf A. Naass Biotechnology Research Centre, Tripoli, Libya Author
  • Waleed R. A. Abusittah Faculty of Medicine, Azzaytuna University, Libya Author
  • Mahmud E. L. Abushhewa Faculty of Medicine, Azzaytuna University, Libya Author

DOI:

https://doi.org/10.54361/ljmr.v14i2.03

Keywords:

Ceftriaxone, Zone of Inhibition, antibacterial efficacy

Abstract

Ceftriaxone (Rocephin)is wide spectrum cephalosporin that has been used for decades for combating infections caused by broad array of pathogens. In this study, the antibiotic ceftriaxone from three different brands was tested for its effectiveness against strains of bacteria like Streptococcus pyrogens, Staphylococcus aureus and Klebsiella pneumonia. The effectiveness of ceftriaxone was estimated by measuring zone of inhibition and compared with standard disc (BD BBL Sensi-Disc 2004/09). The diameters of the inhibitory zones for all brands were ranged from 20 to 33mm±0.5. The present study showed that there is no significant variation amongst the different brands of ceftriaxone in term of their antibacterial effectiveness.

References

Nath SK, Foster GA, Mandell LA, Rotstein C. Antimicrobial activity of ceftriaxone versus cefotaxime: negative effect of serum albumin binding of ceftriaxone. J AntimicrobChemother1994 Jun;33(6):1239-1243. DOI: https://doi.org/10.1093/jac/33.6.1239

Masood H, Naqvi SB, Aslam N. Cost effective analysis of different brands of ceftriaxone available in Karachi Pakistan. Pak J Pharmacol 2008;25:13-19.

Gian Maria Pacifici, Giovanna Marchini11 Clinical Pharmacology of Ceftriaxone in Neonates and Infants: Effects and Pharmacokinetics Systematic Review (Pages: 5751-5777).

Hwang KP, Tang YF, Shen YH. Activity of ertapenem, ciprofloxacin, ceftriaxone, piperacillin-tazobactam, and ampicillin-sulbactam against 12 common clinical isolates of community-acquired bacteraemia. J. Microbial Immunol Infect 2009 Oct;42(5):433-438.

James, C., (2011): Instructor’s guide for microbiology: A laboratory manual. 10th ed. Paperback: Addison Wesley.

Clinical and laboratory standards institute, (2004): 2nd ed.[CLSI].

Hudzicki, J. Kirby-Bauer Disk Diffusion Susceptibility Test Protocol. ASM Microbe Library. American Society for Microbiology, (2009): http://www.microbelibrary.org/component/resource/laboratorytest/3189-kirby-bauer-disk-diffusion-susceptibility-test-protocol

BNF 57, (March 2009): Wholly-owned published, BMJ group and RPS publishing ISBN: 9780853698456.

Syed HA. Masoodand Nousheen Aslam. In Vitro Susceptibility Test of Different Clinical Isolates against Ceftriaxone. Oman Medical Journal 2010, Volume 25, Issue 3. DOI: https://doi.org/10.5001/omj.2010.56

Thapa B, Mahat K. In-vitro Activity of Three Brands of Ceftriaxone against different Clinical Isolates. 2010;49(179):225-7. DOI: https://doi.org/10.31729/jnma.93

Fanta Gashe, Eshetu Mulisa, Mekidim Mekonnen, Gemechu Zeleke. Antimicrobial Resistance Profile of Different Clinical Isolates against Third-Generation Cephalosporins. Journal of Pharmaceutics.2018. 5070742, 7. DOI: https://doi.org/10.1155/2018/5070742

Downloads

Published

31-12-2020

Issue

Section

Articles

How to Cite

1.
Egfair I, Alati RMO, Bakoosh AMO, Alfalos AM, Ruaua MAL, Naass AA, et al. Evaluation the efficacy of three brands of Ceftriaxone against various strains of bacteria by measuring zone of inhibition. LJMR [Internet]. 2020 Dec. 31 [cited 2024 Nov. 24];14(2):22-9. Available from: https://ljmr.ly/index.php/ljmr/article/view/68