The Evaluation of Analgesic activity of Solanum Nigrum
DOI:
https://doi.org/10.54361/Abstract
The present study was undertaken to evaluate the analgesic activities of water extract of leaves and methanolic extract of seeds of Solanum nigrum Linn in experimental animal models. The study was carried out using Swiss albino rats (210- 290g) of female sex. The analgesic activity of Solanum nigrum was assessed by using hot plate and tail flick method. For the determination of analgesic effect, doses of each extract of Solanum nigrum used in the present study were 500 mg/kg body weight (BW). Hot plate test showed a significant increase in the mean reaction time to heat stimuli in hot plate method at 500 mg/kg BW doses throughout the observation period in 1/2 hour, 1 hour and 2 hours after treatment, which was comparable to the standard Ibuprofen and control group. The present study suggests that each extract of Solanum nigrum has significant analgesic and activities.
References
Abdallah Salem Elhwuegi (Ph.D.), Syed Saleem Ahmed (M.D.), Essentials of Bioassay
and screening of Drugs, septamper 282. Dr. Linda Bowring, Guidelines for Developing
a Pain Management Program, A Resource Guide for Health Care Facilities, 5th Edition,
Jennifer M. Edmonds and James A. Chweya, Black nightshades Black nightshades Solanum nigrum L. and related species, 1997
Kevin L. Zacharoff, M.D. Lynette Menefee Pujol, Ph.D, Evelyn Corsini, M.S.W, A Pocket Guide to Pain Management, 4th edition, 2010
P. P. Joy J. Thomas Samuel Mathew Baby P. Skaria, MEDICINAL PLANTS, 1998
Andrea Furlan, MD, PhD and Amy Robidas, RN, CRN(c), MY OPIOID MANAGER, 2015
National Pharmaceutical Council, Section III: Types of Treatments
Indhumathi T, Mohandass S.Int.J.Curr.Microbiol.App.Sci.2014, 3(6), 939-949. [10] Jasim H, Hussein A O, Hameed I H.J.PharmacognosyPhytother. 2015, 7(4), 56-72
Modilal M R D.Int. J. Pure Appl. Zool.2015, 3 (2), 210-215
Waseem Ahmad, Shilpa Singh and Sanjay Kumar, Phytochemical Screening and
antimicrobial study of Euphorbia hirta extracts, Journal of Medicinal Plants Studies 2017; 5(2): 183-186
Hostettmann K, Marston A. Saponins. Vol 1. 1st ed. Cambridge: Cambridge University
Press; 1995
Rancis G, Kerem Z, Makkar HP, Becker K. The biological action of saponins in animal systems: a review. Br J Nutr. 2002; 88(6):587–605
Bachran C, Bachran S, Sutherland M, Bachran D, Fuchs H. Saponins in tumor therapy.
Mini Rev Med Chem. 2008; 8(6):575–584
Sjolander A, Cox JC, Barr IG. ISCOMs: an adjuvant with multiple functions. J Leukoc Biol. 1998; 64(6):713–723
Bachran C, Heisler I, Bachran D, et al. Chimeric toxins inhibit growth of primary oral squamous cell carcinoma cells. Cancer Biol Ther. 2008; 7(2):237–242
Kausar MW, Moeed K, Asif N, Rizwi F, Raza S. Correlation of bilirubin with liver enzymes in patients of falciparum malaria. Int J Pathol 2010; 8(2): 63-7
Rhiouani H, El-Hilaly J, Israili ZH, Lyoussi B. Acute and subchronic toxicity of an aqueous extract of the leaves of Herniaria glabra in rodents. J Ethnopharmacol 2008; 118(3): 378-86
Dr Mahesh Trivedi, Dr Shafee Shaikh, Dr Carl Gwinnutt, PHARMACOLOGY OF OPIOIDS – PART 1 ANAESTHESIA TUTORIAL OF THE WEEK 64, worldanaesthesia@mac.com, 12TH AUGUST 2007
Hozumi, Mizuho, Gifu, and Anesthetic Agents of Plant Origin: A Review of Phytochemicals with Anesthetic Activity, molecules, published: 18 August 2017
Canadian biodiversity Information, address: http://www.cbif.gc.ca/eng/species-bank/candian-poisonous-plants-information-system/all-plant-common-name/black-nightshade/, May 26, 2018
Wikipedia Solanum nigrum last edited by WolfmanSF 12 may 2018
Wikipedia Analgesic last edited by LW001, 12 July 2018
Downloads
Published
Issue
Section
License
Copyright (c) 2018 Ahmed Ibrahim, Ghada Alnaeli, Akram Misbah, Alaa Abuzanoona, Sufyan Emhemed, Muheeb Almahdi, Hunayda Mustafa (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
