Family History among Breast Cancer Patients Attending the National Cancer Centre in Benghazi - Cross-Sectional Study.
DOI:
https://doi.org/10.54361/LJMR.20.2.63Keywords:
Percentage, Breast cancer, Family history, BenghaziAbstract
Background: Breast cancer (BC) is a type of cancer that develops in the cells of the breast. It is the most common cancer diagnosed in women worldwide, although it can also occur in men. Family history is a major risk factor for breast cancer. Familial breast cancer, defined by the clustering of cases within a pedigree, accounts for roughly 20% to 30% of all diagnoses, while high-penetrance germline mutations in genes such as BRCA1 and BRCA2 contribute to 5% to 10% of the total burden. Aim: To determine the percentage of family history of breast cancer among patients attending the National Cancer Centre of Benghazi. Methodology: A cross-sectional study was conducted using convenience sampling of all patients with files during 2023. Results: A total of 124 female patients, of whom 34% were aged 46 to 55 and 28% aged 36 to 45. The mean age of patients was 51.8 ±11.6, the minimum age was 31, and the maximum age was 81. 55% had a family history of breast cancer. Conclusion: This study highlights the significant presence of family history among breast cancer patients attending the National Cancer Centre of Benghazi. More than half of the patients (55%) reported a positive family history of breast cancer, suggesting that hereditary factors may play an important role in the occurrence of the disease among this population. These results emphasise the importance of increasing awareness about family history as a major risk factor for breast cancer and highlight the need for improved screening, early detection programs, and genetic counselling for women with a positive family history to reduce the burden of the disease.
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References
1. Hyuna Sung, Jacques Ferlay, Rebecca L. Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, & Freddie Bray. (2021). Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249.
2. Rondanina G, Puntoni M, Guerrieri-Gonzaga A, Marra D, Bonanni B, DeCensi A. Worry and risk perception of breast cancer in a prevention trial of low-dose tamoxifen in midlife postmenopausal hormone users. The Breast. 2017 Aug 1; 34:108-14.
3. Melvin JC, Wulaningsih W, Hana Z, Purushotham AD, Pinder SE, Fentiman I, Gillett C, Mera A, Holmberg L, Van Hemelrijck M. Family history of breast cancer and its association with disease severity and mortality. Cancer Medicine. 2016 May;5(5):942-9.
4. Haber G, Ahmed NU, Pekovic V. Family history of cancer and its association with breast cancer risk perception and repeat mammography. American journal of public health. 2012 Dec;102(12):2322-9.
5. Johansson A, Christakou AE, Iftimi A, Eriksson M, Tapia J, Skoog L, Benz CC, Rodriguez-Wallberg KA, Hall P, Czene K, Lindström LS. Characterization of benign breast diseases and association with age, hormonal factors, and family history of breast cancer among women in Sweden. JAMA Network Open. 2021 Jun 1;4(6): e2114716-.
6. Liaw YY, Loong FS, Tan S, On SY, Khaw E, Chiew Y, Nordin R, Mat TN, Arulanantham S, Gandhi A. A retrospective study on breast cancer presentation, risk factors, and protective factors in patients with a positive family history of breast cancer. The Breast Journal. 2020 Mar;26(3):469-73.
7. World Health Organization. (2023). Breast cancer: Risk factors and prevention.
8. Claus R. Bartram, Kenneth Offit, & Mary Claire King. (2019). Genetics of breast and ovarian cancer. New England Journal of Medicine, 380, 143–153.
9. Boder, J. E., Elmabrouk Abdalla, F. B., Elfageih, M. A., Abusaa, A., Buhmeida, A., & Collan, Y. (2011). Breast cancer patients in Libya: Comparison with European and central African patients. Oncology Letters, 2(2), 323–330. https://doi.org/10.3892/ol.2011.245
10. Amaijaal, S. D., Al-Aqil, A. A., & Abd Al-Rahim, M. U. (2020). Association of risk factors with breast cancer in Libyan women. Al-Mukhtar Journal of Sciences, 35(3), 218–224.
11. Al-Ghazali, M., et al. (2023). A Cross-Sectional Survey to Estimate the Prevalence of Family History of Colorectal, Breast, and Ovarian Cancer in Derna City, Libya. medRxiv. doi:10.64898/2026.01.27.26343764
12. Elbaruni, S., Elyasir, E., Sayid, M., & Ali, F. (2025). Factors Increasing the Risk of Breast Cancer in Libyan Women. Libyan Medical Journal, 17(3), 529–535. doi:10.69667/lmj. 2517331.References FH
1. Hyuna Sung, Jacques Ferlay, Rebecca L. Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, & Freddie Bray. (2021). Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249.
2. Rondanina G, Puntoni M, Guerrieri-Gonzaga A, Marra D, Bonanni B, DeCensi A. Worry and risk perception of breast cancer in a prevention trial of low-dose tamoxifen in midlife postmenopausal hormone users. The Breast. 2017 Aug 1; 34:108-14.
3. Melvin JC, Wulaningsih W, Hana Z, Purushotham AD, Pinder SE, Fentiman I, Gillett C, Mera A, Holmberg L, Van Hemelrijck M. Family history of breast cancer and its association with disease severity and mortality. Cancer Medicine. 2016 May;5(5):942-9.
4. Haber G, Ahmed NU, Pekovic V. Family history of cancer and its association with breast cancer risk perception and repeat mammography. American journal of public health. 2012 Dec;102(12):2322-9.
5. Johansson A, Christakou AE, Iftimi A, Eriksson M, Tapia J, Skoog L, Benz CC, Rodriguez-Wallberg KA, Hall P, Czene K, Lindström LS. Characterization of benign breast diseases and association with age, hormonal factors, and family history of breast cancer among women in Sweden. JAMA Network Open. 2021 Jun 1;4(6): e2114716-.
6. Liaw YY, Loong FS, Tan S, On SY, Khaw E, Chiew Y, Nordin R, Mat TN, Arulanantham S, Gandhi A. A retrospective study on breast cancer presentation, risk factors, and protective factors in patients with a positive family history of breast cancer. The Breast Journal. 2020 Mar;26(3):469-73.
7. World Health Organization. (2023). Breast cancer: Risk factors and prevention.
8. Claus R. Bartram, Kenneth Offit, & Mary Claire King. (2019). Genetics of breast and ovarian cancer. New England Journal of Medicine, 380, 143–153.
9. Boder, J. E., Elmabrouk Abdalla, F. B., Elfageih, M. A., Abusaa, A., Buhmeida, A., & Collan, Y. (2011). Breast cancer patients in Libya: Comparison with European and central African patients. Oncology Letters, 2(2), 323–330. https://doi.org/10.3892/ol.2011.245
10. Amaijaal, S. D., Al-Aqil, A. A., & Abd Al-Rahim, M. U. (2020). Association of risk factors with breast cancer in Libyan women. Al-Mukhtar Journal of Sciences, 35(3), 218–224.
11. Al-Ghazali, M., et al. (2023). A Cross-Sectional Survey to Estimate the Prevalence of Family History of Colorectal, Breast, and Ovarian Cancer in Derna City, Libya. medRxiv. doi:10.64898/2026.01.27.26343764
12. Elbaruni, S., Elyasir, E., Sayid, M., & Ali, F. (2025). Factors Increasing the Risk of Breast Cancer in Libyan Women. Libyan Medical Journal, 17(3), 529–535. doi:10.69667/lmj. 2517331.
13. El Saghir, N. S., Khalil, M. K., Eid, T., El Kinge, A. R., Charafeddine, M., Geara, F., ... & Shamseddine, A. I. (2007). Trends in epidemiology and management of breast cancer in developing Arab countries: A literature and registry analysis. International Journal of Surgery, 5(4), 225–233.
14. Elzahaf, R. A., & Alaswad, H. A. (2021). Epidemiology of Breast Cancer in Libya: A Systematic Review. Journal of Cancer Policy.
15. Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2024). Global cancer statistics 2024: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians.
16. Bodalal, Z., Azzuz, R., Bendardaf, R., & Cuschieri, A. (2014). Breast cancer in Libya: A review of epidemiological characteristics. East and Central African Journal of Surgery, 19(1), 5–11
17. Cardoso, F., Paluch-Shimon, S., Senkus, E., Curigliano, G., Aapro, M. S., André, F., ... & Winer, E. P. (2019). 5th ESO–ESMO international consensus guidelines for advanced breast cancer (ABC 5). Annals of Oncology, 31(12), 1623–1649.
18. National Comprehensive Cancer Network. (2025). NCCN Clinical Practice Guidelines in Oncology: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic (Version 1.2025). Plymouth Meeting, PA: NCCN.
19. Thalib L, Wedren S, Granath F, Adami HO, Rydh B, Magnusson C, Hall P. Breast cancer prognosis in relation to family history of breast and ovarian cancer. British journal of cancer. 2004 Apr;90(7):1378-81.
20. Tazzite A, Jouhadi H, Saiss K, Benider A, Nadifi S. Relationship between family history of breast cancer and clinicopathological features in Moroccan patients. Ethiopian journal of health sciences. 2013 Jul 24;23(2):150-7.
21. Collaborative Group on Hormonal Factors in Breast Cancer. (2001). Familial breast cancer: Collaborative reanalysis of individual data from 52 epidemiological studies. The Lancet, 358(9291), 1389–1399.
22. American Cancer Society. (2024). Breast cancer facts & figures 2024–2025. Atlanta, GA: American Cancer Society
23. El Saghir, N. S., Keating, N. L., Carlson, R. W., Khoury, K. E., & Fallowfield, L. (2015). Breast cancer management in low- and middle-income countries. The Oncologist, 20(4), 377–384.
24. Abdel-Razeq, H., Mansour, A., & Jaddan, D. (2020). Breast cancer care in the Middle East and North Africa region. Journal of Global Oncology, 6, 1–9.
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