Breast Cancer Patients' Characteristics at a Tertiary Centre in Benghazi, Libya
DOI:
https://doi.org/10.54361/LJMR.20.2.53Keywords:
Breast cancer, Patients, Characteristics, Benghazi , LibyaAbstract
Background: The most common cancer diagnosed in women between the ages of 20 and 50 is breast cancer. Changes in risk factor profiles, improved cancer registration, and early cancer identification have all contributed to an increase in its incidence and death rates over the past three decades. Obesity increases risk in women who are postmenopausal, late menopausal, and have early menarche. At the same time, breastfeeding and physical activity may reduce risk. Although they only occur in a small percentage of instances, mutations in specific genes significantly raise the risk of breast cancer. Aim: To describe the epidemiological characteristics among breast cancer patients at a tertiary centre in Benghazi, Libya. Method: A descriptive cross-sectional study, a total of 105 patients diagnosed with breast cancer were included. Results: The patients were aged Mean ± SD (55.4±12.7), 84(80%) were married, 53.3% BMI ≥ 30 (Obese), 32% had not breastfed their baby, 23% nulliparous, 46% with family history of breast cancer, 31.4% used hormonal therapy, 20% of them had their menarche at an age less than 12 years and 21(20%) had menopausal age higher than 48years.Conclusion: This study reported a high percentage of risk factors that could have an association with their disease, such as obesity, family history, parity, nulliparity, and hormonal issues. The findings also highlight a notable impact of reproductive history and hormonal therapy use.
Downloads
References
1- Sung H., Ferlay J., Siegel R.L., Laversanne M., Soerjomataram I., Jemal A., Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin. 2021; 71:209–249.
2- Iacoviello L, Bonaccio M, de Gaetano G, Donati MB. Epidemiology of breast cancer, a paradigm of the "common soil" hypothesis. Semin Cancer Biol. 2021 Jul; 72:4-10.
3- Łukasiewicz S, Czeczelewski M, Forma A, Baj J, Sitarz R, Stanisławek A. Breast Cancer-Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies-An Updated Review. Cancers (Basel). 2021 Aug 25;13(17):4287.
4- World Health Organization. Global Health Estimates 2016: Disease Burden by Cause, Age, Sex, by Country and by region, 2000–2016. World Health Organization; Geneva, Switzerland: 2018. [(Accessed on 9 July 2021)]. Available online: https://www.who.int/healthinfo/global_burden_disease/esti-mates/en/index1.html.
5- Ferlay J., Ervik M., Lam F., Colombet M., Mery L., Piñeros M., Znaor A., Soerjomataram I., Bray F. Global Cancer Observatory: Cancer Today. International Agency for Research on Cancer; Lyon, France: 2020. Available online: https://gco.iarc.fr/today.
6- Gusbi E, Elgriw N, Zalmat S, et al. Breast cancer in the western part of Libya: Pattern and management (2003-2018). Libyan J Med Sci 2020; 4:65-71.
7- Boder JM, Elmabrouk Abdalla FB, Elfageih MA, Abusaa A, Buhmeida A, Collan Y. Breast cancer patients in Libya: Comparison with European and central African patients. Oncol Lett. 2011 Mar;2(2):323-330.
8- Mufid El Mistiri, Arduino Verdecchia, Ivan Rashid, Nadia El Sahli, Mohamed El Mangush, Massimo Federico. Cancer incidence in Eastern Libya: The first report from the Benghazi Cancer Registry, 2003. Int J Cancer. 2007; 120(2):392-7
9- Amina Muftah Elsaid, Tunis Mahomoud Meidan, and Othman Hammad Tajoury. Knowledge, attitude, and practice of Libyan females attending primary health care centers regarding breast cancer in Benghazi / 2017. World Journal of Advanced Research and Reviews, 2023, 18(02), 080–094
10- American Cancer Society. Breast Cancer Facts & Figures 2019-2020. Atlanta: American Cancer Society, Inc. 2019.
https://www.cancer.org/content/dam/cancer-org/research/cancer-facts
11- Ameigaal, S. D., Ageel, A. A., & Abdoarahem, M. O. Association of Risk Factors with Breast Cancer in Libyan Women. Al-Mukhtar Journal of Sciences 2020; 35(3), 218–224.
12- Benz C.C. Impact of aging on the biology of breast cancer. Crit. Rev. Oncol. 2008; 66:65–74.
13- Shiyanbola O.O., Arao R.F., Miglioretti D.L., Sprague B.L., Hampton J.M., Stout N.K., Kerlikowske K., Braithwaite D., Buist D.S., Egan K.M., et al. Emerging Trends in Family History of Breast Cancer and Associated Risk. Cancer Epidemiol. Biomark. Prev. 2017; 26:1753–1760.
14- Baglia M.L., Tang M.-T.C., Malone K.E., Porter P., Li C.I. Family History and Risk of Second Primary Breast Cancer after in Situ Breast Carcinoma. Cancer Epidemiol. Biomark. Prev. 2018; 27:315–320.
15- Brewer H.R., Jones M.E., Schoemaker M.J., Ashworth A., Swerdlow A.J. Family history and risk of breast cancer: An analysis accounting for family structure. Breast Cancer Res. Treat. 2017; 165:193–200.
16- Shiovitz S., Korde L.A. Genetics of breast cancer: A topic in evolution. Ann. Oncol. 2015; 26:1291–1299.
17- Albrektsen G., Heuch I., Hansen S., Kvåle G. Breast cancer risk by age at birth, time since birth and time intervals between births: Exploring interaction effects. Br. J. Cancer. 2004; 92:167–175.
18- Julie R Palmer, Lauren A Wise, Elizabeth E Hatch, et al. Prenatal Diethylstilbestrol Exposure and Risk of Breast Cancer. Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1509-14.
19- Checka C.M., Chun J.E., Schnabel F.R., Lee J., Toth H. The Relationship of Mammographic Density and Age: Implications for Breast Cancer Screening. Am. J. Roentgenol. 2012;198: W292–W295.
20- Schacht D.V., Yamaguchi K., Lai J., Kulkarni K., Sennett C.A., Abe H. Importance of a Personal History of Breast Cancer as a Risk Factor for the Development of Subsequent Breast Cancer: Results from Screening Breast MRI. Am. J. Roentgenol. 2014; 202:289–292.
21- Zhang Q., Liu J., Ao N., Yu H., Peng Y., Ou L., Zhang S. Secondary cancer risk after radiation therapy for breast cancer with different radiotherapy techniques. Sci. Rep. 2020; 10:1220.
22- Chen X., Wang Q., Zhang Y., Xie Q., Tan X. Physical Activity and Risk of Breast Cancer: A Meta-Analysis of 38 Cohort Studies in 45 Study Reports. Value Health. 2018; 22:104–128.
23- Wang X., Hui T.-L., Wang M.-Q., Liu H., Li R.-Y., Song Z.-C. Body Mass Index at Diagnosis as a Prognostic Factor for Early-Stage Invasive Breast Cancer after Surgical Resection. Oncol. Res. Treat. 2019; 42:195–201.
24- Li M, Han M, Chen Z, Tang Y, Ma J, Zhang Z, Liu Z, Zhang N, Xi C, Liu J, Tian D, Wang X, Huang X, Chen J, Wang W, Zhai S. Does marital status correlate with the female breast cancer risk? A systematic review and meta-analysis of observational studies. PLoS One. 2020 ; 15(3): e0229899.
25- Bodalal Z, Azzuz R, Bendardaf R. Risk factors associated with breast cancer in Libyan women. World J Surg Oncol. 2014; 12:225.
26- Abdelaziz AH, Ibrahim RM, Basha MAA. Breast cancer risk factors among Egyptian women: a case-control study. Asian Pac J Cancer Prev. 2021;22(4):1123–1130.
27- Frikha M, Daoud J, Boussen H, et al. Breast cancer epidemiology and risk factors in North African women. Pan Afr Med J. 2022; 41:102.
28- Kuchenbaecker KB, Hopper JL, Barnes DR, et al. Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. JAMA. 2017;317(23):2402–2416.
29- Mavaddat N, Antoniou AC, Easton DF, Garcia-Closas M. Genetic susceptibility to breast cancer. Mol Oncol. 2010;4(3):174–191.
30- Abujamous L, Ahmed I, Ahen Y, et al. Somatic mutations in Middle East and North Africa breast cancer patients: a systematic review. Oncologist. 2025;30(9): oyaf205.
31- Mane N, Fouqani A, Mrah S, et al. Obesity and risk of pre- and postmenopausal breast cancer in Africa: a systematic review. Curr Oncol. 2025;32(3):167
32- Ajabnoor GMA. The molecular and genetic interactions between obesity and breast cancer risk. Medicina. 2023;59(7):1338
33- Dehesh T, Fadaghi S, Seyedi M, et al. The relation between obesity and breast cancer risk in women by considering menstruation status and geographical variations: a systematic review and meta-analysis. BMC Women's Health. 2023; 23:392.
34- Elbaruni S, Elyasir E, Sayid M, et al. Factors increasing the risk of breast cancer in Libyan women. Libyan Medical Journal. 2025.
35- Iyengar NM, Hudis CA, Dannenberg AJ. Obesity and inflammation in breast cancer. Annu Rev Med. 2015; 66:297–309.
36- Lambe M, Hsieh CC, Chan HW, et al. Parity, age at first birth, and the risk of breast cancer. Cancer Causes Control. 1996;7(3):231–239.
37- Alotaibi RM, Rezk HR, Juliana CI, et al. Breast cancer risk factors in women in the Gulf region. BMC Women's Health. 2022; 22:412.
38- Shamseddine A, Saleh A, Charafeddine M, et al. Breast cancer epidemiology in the Arab world. Cancer. 2021;127(4):541–549.
39- MacMahon B, Cole P, Lin TM, et al. Age at first birth and breast cancer risk. Bull World Health Organ. 1970;43(2):209–221.
40- Islami F, Liu Y, Jemal A, et al. Breastfeeding and breast cancer risk by receptor status. Ann Oncol. 2015;26(12):2398–2407.
41- Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and breastfeeding: collaborative reanalysis. Lancet. 2002;360(9328):187–195.
42- Lamchabbek N, Elattabi C, Bour A, et al. Associations between dietary factors and breast cancer risk: evidence from the MENA region. Nutrients. 2025;17(3):394.
43- Henderson BE, Ross RK, Pike MC. Endogenous hormones and breast cancer. Cancer Res. 1982;42(8):3232–3239.
44- Chlebowski RT, Anderson GL. Menopausal hormone therapy and breast cancer. J Natl Cancer Inst. 2023;115(5):507–515.
45- Elhawari WA, Lehmidi TE, Awad HR, et al. Demographic and clinical characteristics of breast cancer at the National Cancer Center in Benghazi. Libyan Journal of Veterinary and Medical Sciences. 2025.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Amina Elsaid , Khadija R. Shaglouf , Sana H. Hamad , Sana H. Hamad , Asmaa A. Boshugma (Author)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Open Access Policy
Libyan journal of medical Research (LJMR).is an open journal, therefore there are no fees required for downloading any publication from the journal website by authors, readers, and institution.
The journal applies the license of CC BY (a Creative Commons Attribution 4.0 International license). This license allows authors to keep ownership f the copyright of their papers. But this license permits any user to download , print out, extract, reuse, archive, and distribute the article, so long as appropriate credit is given to the authors and the source of the work.
The license ensures that the article will be available as widely as possible and that the article can be included in any scientific archive.
Editorial Policy
The publication of an article in a peer reviewed journal is an essential model for Libyan journal of medical Research (LJMR). It is necessary to agree upon standards of expected ethical behavior for all parties involved in the act of publishing: the author, the journal editorial, the peer reviewer and the publisher.
Any manuscript or substantial parts of it, submitted to the journal must not be under consideration by any other journal. In general, the manuscript should not have already been published in any journal or other citable form, although it may have been deposited on a preprint server. Authors are required to ensure that no material submitted as part of a manuscript infringes existing copyrights, or the rights of a third party.
Authorship Policy
The manuscript authorship should be limited to those who have made a significant contribution and intellectual input to the research submitted to the journal, including design, performance, interpretation of the reported study, and writing the manuscript. All those who have made significant contributions should be listed as co-authors.
Others who have participated in certain substantive aspects of the manuscript but without intellectual input should only be recognized in the acknowledgements section of the manuscript. Also, one of the authors should be selected as the corresponding author to communicate with the journal and approve the final version of the manuscript for publication in the LJMR.
Peer-review Policy
- All the manuscripts submitted to LJMR will be subjected to the double-blinded peer-review process;
- The manuscript will be reviewed by two suitable experts in the respective subject area.
- Reports of all the reviewers will be considered while deciding on acceptance/revision or rejection of a manuscript.
- Editor-In-Chief will make the final decision, based on the reviewer’s comments.
- Editor-In-Chief can ask one or more advisory board members for their suggestions upon a manuscript, before making the final decision.
- Associate editor and review editors provide administrative support to maintain the integrity of the peer-review process.
- In case, authors challenge the editor’s negative decision with suitable arguments, the manuscript can be sent to one more reviewer and the final decision will be made based upon his recommendations.












https://portal.issn.org/resource/ISSN/2413-6069