Enamel Matrix Derivative (Emdogain) for Wound Healing and Bone Regeneration: A Short-Review
DOI:
https://doi.org/10.54361/LJMR.19.049Abstract
Emdogain® is a unique gel containing an enamel matrix derivative of protein origin. This mixture of natural proteins can induce biological processes; that usually take place during development/regeneration of periodontium by stimulating certain cells involved in the healing process of soft/hard tissues. This agent is intended to improve the quality of patient’s life by reducing pain, swelling and systemic inflammation after completing treatment procedures. Therefore, the aim of this short-review was to understand the rationale behind the use of Emdogain® as a smart biomaterial for periodontal and peri-implant regenerations; and further to provide a clinical perspective for Oral Surgeons and Periodontists in Libya. Keywords: Enamel Matrix Derivative (Emdogain®); Implantology; Periodontology; Wound Healing; Regeneration.
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Grandin HM, Gemperli AC, Dard M. Enamel matrix derivative: a review of cellular effects in vitro and a model of molecular arrangement and functioning. Tissue Eng. Part B Rev. 2012; 18(3): 181-202.
Rathva VJ. Enamel matrix protein derivatives: role in periodontal regeneration. Clin. Cosmet. Investing. Dent. 2011; 3: 79-92.
Park JB. Clinical application of enamel matrix derivative for periodontal regeneration and treatment of peri-Implantitis. In Periodontology and Dental Implantology. 2018; Nov 5. IntechOpen.
Venezia E, Goldstein M, Boyan BD, Schwartz Z. The use of enamel matrix derivative in the treatment of periodontal defects: a literature review and meta-analysis. Crit. Rev. Oral Biol. Med. 2004; 15(6): 382-02.
Miron RJ, Dard M, Weinreb M. Enamel matrix derivative, inflammation and soft tissue wound healing. J Periodontal Res. 2015;50(5):555-69.
Sculean A, Schwarz F, Becker J, Brecx M. The application of an enamel matrix protein derivative (Emdogain®) in regenerative periodontal therapy: A review. Med. Princ. Pract. 2007;16(3):167-80.
Tsai SJ, Ding YW, Shih MC, Tu YK. Systematic review and sequential network meta‐analysis on the efficacy of periodontal regenerative therapies. J. Clin. Periodontol.. 2020;47(9):1108-20.
Stavropoulos A, Bertl K, Spineli LM, Sculean A, Cortellini P, Tonetti M. Medium‐and long‐term clinical benefits of periodontal regenerative/reconstructive procedures in intrabony defects: Systematic review and network meta‐analysis of randomized controlled clinical studies. J. Clin. Periodontol. 2021; 48(3): 410-30.
Meza Mauricio J, Furquim CP, Bustillos-Torrez W, Soto-Peñaloza D, Peñarrocha-Oltra D, Retamal-Valdes B, et al., Does enamel matrix derivative application provide additional clinical benefits in the treatment of maxillary Miller class I and II gingival recession? A systematic review and meta-analysis. Clin. Oral Investig. 2021; 25(4): 1613-26.
Fan L, Wu D. Enamel matrix derivatives for periodontal regeneration: recent developments and future perspectives. J Healthc Eng. 2022:1-10.
Lyngstadaas SP, Wohlfahrt JC, Brookes SJ, Paine ML, Snead ML, Reseland JE. Enamel matrix proteins; old molecules for new applications. Orthodontics Craniofacial Res. 2009; 12(3): 243-53.
Hoang AM, Oates TW, Cochran DL. In vitro wound healing responses to enamel matrix derivative. J. Periodontol. 2000; 71(8): 1270-7.
Parkar MH, Tonetti M. Gene expression profiles of periodontal ligament cells treated with enamel matrix proteins in vitro: analysis using cDNA arrays. J. Periodontol. 2004;75(11):1539-46.
Almqvist S, Kleinman HK, Werthén M, Thomsen P, Ågren MS. Effects of amelogenins on angiogenesis-associated processes of endothelial cells. J. Wound Care. 2011;20(2):68-75.
Miron RJ, Guillemette V, Zhang Y, Chandad F, Sculean A. Enamel matrix derivative in combination with bone grafts: A review of the literature. Quintessence Int. 2014;45(6):475-87.
Amin HD, Olsen I, Knowles J, Dard M, Donos N. Interaction of enamel matrix proteins with human periodontal ligament cells. Clin. Oral Investig. 2016;20(2):339-47.
Institut Straumann AG. Straumann® Biomaterials Master any Challenge, Product Portfolio; 2019. https://www.straumann.com/my/en/dentalprofessionals/productsandsolutions/biomaterials/straumann-mdogain/Straumann-Emdogain.html
Roos‐Jansåker AM, Renvert S, Egelberg J. Treatment of peri‐implant infections: a literature review. J. Clin. Periodontol. 2003;30(6):467-85.
Froum SJ, Froum SH, Rosen PS. Successful management of peri-implantitis with a regenerative approach: a consecutive series of 51 treated implants with 3-to 7.5-year follow-up. Int. J. Periodontics Restorative Dent. 2012;32(1):11-20.
Furtado Guimarães G, Cavalcanti de Araújo V, Nery JC, Peruzzo DC, Borges Soares A. Microvessel density evaluation of the effect of enamel matrix derivative on soft tissue after implant placement: a preliminary study. Int. J. Periodontics Restorative Dent. 2015;35(5):732-38.
Al-Hezaimi K, Al-Fahad H, O’Neill R, Shuman L, Griffin T. The effect of enamel matrix protein on gingival tissue thickness in vivo. Odontology. 2012;100(1):61-6.
Ozcelik O, Haytac MC, Seydaoglu G. Immediate post‐operative effects of different periodontal treatment modalities on oral health‐related quality of life: a randomized clinical trial. J. Clin. Periodontol. 2007;34(9):788-96.
Alberti A, Francetti L, Taschieri S, Corbella S. The applications of enamel matrix derivative in implant dentistry: A narrative review. Materials. 2021;14(11):3045.
Villa O, Wohlfahrt JC, Mdla I, Petzold C, Reseland JE, Snead ML, et al., Proline‐rich peptide mimics effects of enamel matrix derivative on rat oral mucosa incisional wound healing. J. Periodontol. 2015;86(12):1386-95.
Isehed C, Svenson B, Lundberg P, Holmlund A. Surgical treatment of peri‐implantitis using enamel matrix derivative, an RCT: 3‐and 5‐year follow‐up. J. Clin. Periodontol. 2018;45(6):744-53.
Li G, Hu J, Chen H, Chen L, Zhang N, Zhao L, et al., Enamel matrix derivative enhances the proliferation and osteogenic differentiation of human periodontal ligament stem cells on the titanium implant surface. Organogenesis. 2017;13(3):103-13.
Shi B, Andrukhov O, Özdemir B, Tabrizi HA, Dard M, Rausch-Fan X. Effect of enamel matrix derivative on the angiogenic behaviors of human umbilical vein endothelial cells on different titanium surfaces. Dent. Mater. J. 2017;36(4):381-6.
Chatzopoulos GS, Anastasopoulos M, Zarenti S, Doufexi AE, Tsalikis L. Flapless application of enamel matrix derivative in non‐surgical periodontal treatment: A systematic review. Int. J. Dent. Hyg. 2022;20(2):422-33.
Savage A, Eaton KA, Moles DR, Needleman I. A systematic review of definitions of periodontitis and methods that have been used to identify this disease. J. Clin. Periodontol. 2009;36(6):458-67.
Maymon‐Gil T, Weinberg E, Nemcovsky C, Weinreb M. Enamel matrix derivative promotes healing of a surgical wound in the rat oral mucosa. J. Periodontol. 2016; 87(5): 601-9.
Keila S, Nemcovsky CE, Moses O, Artzi Z, Weinreb M. In vitro effects of enamel matrix proteins on rat bone marrow cells and gingival fibroblasts. J. Dent. Res. 2004;83(2):134-8.
Zeldich E, Koren R, Nemcovsky C, Weinreb M. Enamel matrix derivative stimulates human gingival fibroblast proliferation via ERK. J. Dent. Res. 2007;86(1):41-6.
Zeldich E, Koren R, Dard M, Weinberg E, Weinreb M, Nemcovsky CE. Enamel matrix derivative induces the expression of tissue inhibitor of matrix metalloproteinase‐3 in human gingival fibroblasts via extracellular signal‐regulated kinase. J. Periodontal Res. 2010;45(2):200-6.
Thoma DS, Villar CC, Carnes DL, Dard M, Patricia Chun YH, Cochran DL. Angiogenic activity of an enamel matrix derivative (EMD) and EMD‐derived proteins: An experimental study in mice. J. Clin. Periodontol. 2011;38(3):253-60.
Miron RJ, Sculean A, Cochran DL, Froum S, Zucchelli G, Nemcovsky C, et al., Twenty years of enamel matrix derivative: the past, the present and the future. J. Clin. Periodontol. 2016;43(8):668-83.
Sanz M, Tonetti MS, Zabalegui I, Sicilia A, Blanco J, Rebelo H, et al., Treatment of intrabony defects with enamel matrix proteins or barrier membranes: Results from a multicenter practice‐based clinical trial. J. Periodontol. 2004;75(5):726-33.
Tonetti MS, Fourmousis I, Suvan J, Cortellini P, Brägger U, Lang NP, European Research Group on Periodontology (ERGOPERIO). Healing, post‐operative morbidity and patient perception of outcomes following regenerative therapy of deep intrabony defects. J. Clin. Periodontol. 2004;31(12):1092-8.
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