Assessment of Serum Vitamin D and Calcium Levels among Patients with Hypothyroidism: A Comparative Study in Albayda, Libya

Authors

  • Nusieba A. Ibrahim Department of Pharmacology and Toxicology, Faculty of Pharmacy, Omar Al-Mukhtar University, Albayda, Libya Author
  • Yahya Saber E. Mansour Department of Pharmacology and Toxicology, Faculty of Pharmacy, Omar Al-Mukhtar University, Albayda, Libya Author

DOI:

https://doi.org/10.54361/LJMR.19.2.34

Keywords:

Vitamin D, Calcium, Hypothyroidism, Hypovitaminosis D, Albayda

Abstract

Purpose: Vitamin D is essential for the proper functioning of numerous organs, including the thyroid gland. Therefore, a deficiency in vitamin D is considered a potential risk factor for developing various thyroid disorders, particularly hypothyroidism. The present study aimed to evaluate the serum concentrations of vitamin D and calcium in individuals who have been diagnosed with hypothyroidism. Materials and Methods The research was conducted on a cohort of 150 patients with hypothyroidism at the Department of Internal Medicine, Albayda Medical Center, in Albayda, Libya. Serum levels of vitamin D, calcium, thyroid-stimulating hormone (TSH), and thyroid hormones (T3 and T4) were measured in all participants. A control group consisting of 100 healthy individuals was used for comparison. Vitamin D deficiency was defined as serum vitamin D concentrations below 20 ng/mL. Results: Our findings indicated that patients with hypothyroidism exhibited significantly reduced serum levels of both vitamin D and calcium compared to the control group (P<0.05). Conclusion: Based on these results, it is strongly advised that individuals with hypothyroidism be screened for vitamin D and calcium deficiencies and, if necessary, receive appropriate supplementation.

Downloads

Download data is not yet available.

References

1. Holick M. F. (1987). Photosynthesis of vitamin D in the skin: effect of environmental and life-style variables. Federation proceedings, 46(5), 1876–1882.

2. Dominguez, L. J., Farruggia, M., Veronese, N., & Barbagallo, M. (2021). Vitamin D Sources, Metabolism, and Deficiency: Available Compounds and Guidelines for Its Treatment. Metabolites, 11(4), 255.

3. Chung, M., Balk, E. M., Brendel, M., Ip, S., Lau, J., Lee, J., Lichtenstein, A., Patel, K., Raman, G., Tatsioni, A., Terasawa, T., & Trikalinos, T. A. (2009). Vitamin D and calcium: a systematic review of health outcomes. Evidence report/technology assessment, (183), 1–420.

4. Khakisahneh, S., Zhang, X. Y., Nouri, Z., Hao, S. Y., Chi, Q. S., & Wang, D. H. (2019). Thyroid hormones mediate metabolic rate and oxidative, anti-oxidative balance at different temperatures in Mongolian gerbils (Meriones unguiculatus). Comparative biochemistry and physiology. Toxicology & Pharmacology: CBP, 216, 101–109.

5. Duran, İ. D., Gülçelik, N. E., Bulut, B., Balcı, Z., Berker, D., & Güler, S. (2019). Differences in Calcium Metabolism and Thyroid Physiology After Sleeve Gastrectomy and Roux-En-Y Gastric Bypass. Obesity surgery, 29(2), 705–712.

6. Unnikrishnan, A. G., Kalra, S., Sahay, R. K., Bantwal, G., John, M., & Tewari, N. (2013). Prevalence of hypothyroidism in adults: An epidemiological study in eight cities of India. Indian journal of endocrinology and metabolism, 17(4), 647–652.

7. Kivity, S., Agmon-Levin, N., Zisappl, M., Shapira, Y., Nagy, E. V., Dankó, K., Szekanecz, Z., Langevitz, P., & Shoenfeld, Y. (2011). Vitamin D and autoimmune thyroid diseases. Cellular & molecular immunology, 8(3), 243–247.

8. Tamer, G., Arik, S., Tamer, I., & Coksert, D. (2011). Relative vitamin D insufficiency in Hashimoto's thyroiditis. Thyroid: official journal of the American Thyroid Association, 21(8), 891–896.

9. Yasuda, T., Okamoto, Y., Hamada, N., Miyashita, K., Takahara, M., Sakamoto, F., Miyatsuka, T., Kitamura, T., Katakami, N., Kawamori, D., Otsuki, M., Matsuoka, T. A., Kaneto, H., & Shimomura, I. (2012). Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves' disease. Endocrine, 42(3), 739–741.

10. Zhou, H., Xu, C., & Gu, M. (2009). Vitamin D receptor (VDR) gene polymorphisms and Graves' disease: a meta-analysis. Clinical endocrinology, 70(6), 938–945.

11. Appunni, S., Rubens, M., Ramamoorthy, V., Saxena, A., Tonse, R., Veledar, E., & McGranaghan, P. (2021). Association between vitamin D deficiency and hypothyroidism: results from the National Health and Nutrition Examination Survey (NHANES) 2007-2012. BMC endocrine disorders, 21(1), 224.

12. Kaplan M. M. (1999). Clinical perspectives in the diagnosis of thyroid disease. Clinical chemistry, 45(8 Pt 2), 1377–1383.

13. Al-Ali, A., AlElq, A., Al-Turki, H., Al-Mulhim, F., & Sadat-Ali, M. (2009). Vitamin D levels in healthy men in eastern Saudi Arabia. Annals of Saudi medicine, 29(5), 378–382.

14. Mackawy, A. M., Al-Ayed, B. M., & Al-Rashidi, B. M. (2013). Vitamin D deficiency and its association with thyroid disease. Int J Health Sci (Qassim), 7(3):267-75.

15. Elsammak, M. Y., Al-Wossaibi, A. A., Al-Howeish, A., & Alsaeed, J. (2011). High prevalence of vitamin D deficiency in the sunny Eastern region of Saudi Arabia: a hospital-based study. Eastern Mediterranean health journal, 17(4), 317–322.

16. Lippi, G., Montagnana, M., Meschi, T., & Borghi, L. (2012). Vitamin D concentration and deficiency across different ages and genders. Aging clinical and experimental research, 24(5), 548–551.

17. Hashemipour, S., Larijani, B., Adibi, H., Javadi, E., Sedaghat, M., Pajouhi, M., Soltani, A., Shafaei, A. R., Hamidi, Z., Fard, A. R., Hossein-Nezhad, A., & Booya, F. (2004). Vitamin D deficiency and causative factors in the population of Tehran. BMC public health, 4, 38.

18. Heshmat, R. Y., Mohammad, K. M., & Ranjbar, G. H. (2008). Vitamin D deficiency in Iran: A multi-center study among different urban areas. Iran J Public Health, 37(suppl): 72-8.

19. Salman, S., Khouzami, M., Harb, M., Saleh, B., Boushnak, M. O., Moussa, M. K., & Mohsen, Z. H. (2021). Prevalence and Predictors of Vitamin D Inadequacy: A Sample of 2,547 Patients in a Mediterranean Country. Cureus, 13(5), e14881.

20. Faid, F. E., Alsheekh, A. M., Abais, M. F., & Eljamay, S. M. (2024). Vitamin D Deficiency Relationship with Age and Gender. Derna Academy Journal for Applied Sciences, 3(2), 153-160.

Downloads

Published

01-07-2025

Issue

Section

Articles

How to Cite

1.
Ibrahim N, Mansour Y. Assessment of Serum Vitamin D and Calcium Levels among Patients with Hypothyroidism: A Comparative Study in Albayda, Libya. LJMR [Internet]. 2025 Jul. 1 [cited 2025 Oct. 2];19(2):283-8. Available from: http://ljmr.ly/index.php/ljmr/article/view/437

Similar Articles

1-10 of 12

You may also start an advanced similarity search for this article.