Klebsiella pneumoniae Antibiotic Resistance Pattern Towards Antimicrobial Agents in Urinary Tract Infection Patients in Zawia City / Libya
DOI:
https://doi.org/10.54361/LJM18-06Keywords:
Urinary tract infections (UTIs), pneumonia, Antibiotic resistance, Meropenem, Tetracycline,, ZawiaAbstract
Urinary Tract Infections (UTIs) represent a significant public health concern, contributing to serious health issues, extensive antibiotic use globally, and ranking as the second most common reason for clinical consultations in community settings. Various bacteria, particularly from the Enterobacteriaceae family, including Klebsiella spp., are implicated in the etiology of UTIs. This study focused on assessing the prevalence and antibiotic resistance patterns of uropathogenic K. pneumoniae across different age groups and genders. A total of 819 urine samples were collected from patients visiting Zawia hospitals and clinics between September 2022 and February 2023. Identification of K. pneumoniae was performed through colony morphology, Gram staining, and biochemical assays, followed by antibiotic susceptibility testing. Out of all samples, 271 (33.07%) exhibited significant bacterial growth. The incidence of UTIs was notably higher in females (40.15%) compared to males (20.6%). The age group of 1-9 years showed the highest susceptibility to UTIs at 35.4%. K. pneumoniae accounted for 23.9% of all UTI cases, with a higher prevalence in males (31.14%) than in females (21.9%). The 1-9 year age group was identified as the most vulnerable to K. pneumoniae infections, with a prevalence of 29.2%. K. pneumoniae demonstrated a high susceptibility rate of 86.2% to Meropenem, while showing significant resistance to Tetracycline at 70.8%. The findings indicate a high prevalence of UTIs in the 1-9 year age group, with females at greater risk. Males exhibited a higher susceptibility to K. pneumoniae, particularly in the younger age group. The bacterium showed strong sensitivity to Meropenem and considerable resistance to Tetracycline. Increased awareness and regular monitoring of antimicrobial usage in healthcare settings are essential to mitigate resistance rates and combat this pathogen.
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