First 48 Hours of Urine Output in Neonates: Physiological Transition, Clinical Uncertainty, and Evolving Diagnostic Perspectives
DOI:
https://doi.org/10.54361/LJMR.20.2.39Keywords:
Urine Output, Neonates:, Physiological TransitionAbstract
Background: Down syndrome is the most common chromosomal disorder worldwide, associated with distinct cytogenetic patterns and maternal risk factors. Understanding these features in Benghazi is essential for guiding local healthcare interventions. Aim: To determine the prevalent cytogenetic types and demographic factors associated with Down syndrome diagnosed at Benghazi’s First International Laboratory. Materials and Methods This retrospective study analyzed 200 karyotype records from 2020 to 2025. Cytogenetic classification and demographic data, including maternal age and consanguinity, were assessed. Results: Trisomy 21 accounted for the majority of cases (82%), followed by mosaicism (12%) and translocation (6%). Advanced maternal age (>35 years) was significantly associated with Trisomy 21, while consanguinity was observed in 30% of translocation cases. Conclusions: Trisomy 21 is the predominant form of Down syndrome in Eastern Libya and is strongly linked to advanced maternal age. Consanguinity may contribute to rarer subtypes such as translocation. These findings highlight the importance of maternal health awareness and genetic counseling initiatives in the region.
Downloads
References
1. Chowdhry BK, et al. Timing of first urine void in healthy newborns. J Family Med Prim Care. 2024;13: doi:10.4103/jfmpc.jfmpc
2. Kliegman RM, St Geme JW. Nelson textbook of pediatrics. 21st ed. Philadelphia (PA): Elsevier; 2020.
3. Clark DA, et al. Normal voiding patterns in neonates. Pediatrics. 1977;60(3):374–377. doi:10.1542/peds.60.3.374
4. Guignard JP, Drukker A. Why do newborn infants have a high plasma creatinine? Pediatrics. 1999;103(4):e49. doi:10.1542/peds.103.4.e49
5. Modi N. Fluid and electrolyte balance in the neonate. Semin Neonatol. 2003;8(4):287–295. doi:10.1016/S1084-2756(03)00041-1
6. Jetton JG, Askenazi DJ. Update on neonatal acute kidney injury. Curr Opin Pediatr. 2012;24(2):191–196. doi:10.1097/MOP.0b013e32834f62d5
7. Malbrain MLNG, et al. Urine output in acute kidney injury: importance and limitations. Ann Intensive Care. 2024;14:. doi:10.1186/s13613-024-01342-
8. Meena J, et al. Acute kidney injury in neonates: a meta-analysis. Pediatrics. 2024;154(1):e2023065182. doi:10.1542/peds.2023-065182
9. Chen CC, et al. Neurodevelopment after neonatal AKI. Kidney Int Rep. 2023;8(9):1784–1791. doi:10.1016/j.ekir.2023.06.020
10. Girão ATMB, et al. Urine output thresholds and AKI prediction. Clin J Am Soc Nephrol. 2024;. doi:10.2215/CJN.0000000000000534
11. Hussein A, et al. Neonatal AKI practices in NICUs. J Perinatol. 2026. doi:10.1038/s41372-026-02635-8
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Ramadan M. Sarrab, Abdalmonam A. Majbar, Keria H. Sheha (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Open Access Policy
Libyan journal of medical Research (LJMR).is an open journal, therefore there are no fees required for downloading any publication from the journal website by authors, readers, and institution.
The journal applies the license of CC BY (a Creative Commons Attribution 4.0 International license). This license allows authors to keep ownership f the copyright of their papers. But this license permits any user to download , print out, extract, reuse, archive, and distribute the article, so long as appropriate credit is given to the authors and the source of the work.
The license ensures that the article will be available as widely as possible and that the article can be included in any scientific archive.
Editorial Policy
The publication of an article in a peer reviewed journal is an essential model for Libyan journal of medical Research (LJMR). It is necessary to agree upon standards of expected ethical behavior for all parties involved in the act of publishing: the author, the journal editorial, the peer reviewer and the publisher.
Any manuscript or substantial parts of it, submitted to the journal must not be under consideration by any other journal. In general, the manuscript should not have already been published in any journal or other citable form, although it may have been deposited on a preprint server. Authors are required to ensure that no material submitted as part of a manuscript infringes existing copyrights, or the rights of a third party.
Authorship Policy
The manuscript authorship should be limited to those who have made a significant contribution and intellectual input to the research submitted to the journal, including design, performance, interpretation of the reported study, and writing the manuscript. All those who have made significant contributions should be listed as co-authors.
Others who have participated in certain substantive aspects of the manuscript but without intellectual input should only be recognized in the acknowledgements section of the manuscript. Also, one of the authors should be selected as the corresponding author to communicate with the journal and approve the final version of the manuscript for publication in the LJMR.
Peer-review Policy
- All the manuscripts submitted to LJMR will be subjected to the double-blinded peer-review process;
- The manuscript will be reviewed by two suitable experts in the respective subject area.
- Reports of all the reviewers will be considered while deciding on acceptance/revision or rejection of a manuscript.
- Editor-In-Chief will make the final decision, based on the reviewer’s comments.
- Editor-In-Chief can ask one or more advisory board members for their suggestions upon a manuscript, before making the final decision.
- Associate editor and review editors provide administrative support to maintain the integrity of the peer-review process.
- In case, authors challenge the editor’s negative decision with suitable arguments, the manuscript can be sent to one more reviewer and the final decision will be made based upon his recommendations.
https://portal.issn.org/resource/ISSN/2413-6069
