Cytotoxic activity of Helianthemum Lippii

Authors

  • Salah M. Bensaber Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya Author
  • Ibrahim A. Mrema Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya Author
  • Mousa I. Jaeda Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya Author
  • Abdul M. Gbaj Department of Medicinal Chemistry, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya Author

DOI:

https://doi.org/10.54361/ljmr.v8i2-01

Keywords:

Medicinal plants, Cytotoxicity, Cancer, Helianthemum lippii

Abstract

Cancer is one of the most prominent human diseases which have stimulated scientific and commercial interest in the discovery of new anticancer agents from natural sources. The current study investigates the cytotoxic activity ofethanolic extracts of Helianthemum lippii used locally for the treatment of cancer using the MTT assay on the HeLa cell line. Helianthemum lippii showed activity comparable to the reference compound Cisplatin. The results justify the use of Helianthemum lippii in traditional treatment of cancer.

References

Pandya, Gupta, Pandav, Barthwal, Jayaram and Kumar (2012) DNA binding studies of Vinca alkaloids: experimental and computational evidence. Nat Prod Commun, 7, 3: 305-309.

Sears and Boger (2015) Total synthesis of vinblastine, related natural products, and key analogues and development of inspired methodology suitable for the systematic study of their structure-function properties. Acc Chem Res, 48, 3: 653-662.

Nwodo, Ibezim, Simoben and Ntie-Kang (2015) Exploring cancer therapeutics with natural products from African medicinal plants, part II: alkaloids, terpenoids and flavonoids. Anticancer Agents Med Chem,

Singh, Shedbalkar, Wadhwani and Chopade (2015) Bacteriagenic silver nanoparticles: synthesis, mechanism, and applications. Appl Microbiol Biotechnol 99. 11: 4579-4593.

Hosseini and Ghorbani (2015) Cancer therapy with phytochemicals: evidence from clinical studies. Avicenna J Phytomed, 5 (2): 84-97.

Bennur, Kumar, Zinjarde and Javdekar (2015) Nocardiopsis species: Incidence, ecological roles and adaptations. Microbiol Res, 174: 33-47.

Khan, Saif, Quradha, Ali, Rauf and Khan (2015) Antioxidant, antimicrobial and urease inhibiting activities of methanolic extracts from Cyphostemma digitatum stem and roots. Nat Prod Res, 1-3.

Shah, Sadiq, Shah and Ullah. Antioxidant, total phenolic contents and antinociceptive potential of Teucrium stocksianum methanolic extract in different animal models. BMC Complement Altern Med, 14: 181.

Nguyen, Pham, Pham, Quach, Pudhom, Hansen and Nguyen (2015) Chemical constituents from Sonneratia ovata Backer and their in vitro cytotoxicity and acetylcholinesterase inhibitory activities. Bioorg Med Chem Lett, 25, 11: 2366-2371.

Oka, Maeda, Koga, Kato and Saito (1992) A modified colorimetric MTT assay adapted for primary cultured hepatocytes: application to proliferation and cytotoxicity assays. Biosci Biotechnol Biochem, 56, 9: 1472-1473

Downloads

Published

30-06-2014

Issue

Vol. 8 No. 2 (2014)

Section

Articles

License

Copyright (c) 2014 Libyan Journal of Medical Research

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

1.
Bensaber SM, Mrema IA, Jaeda MI, Gbaj AM. Cytotoxic activity of Helianthemum Lippii. LJMR [Internet]. 2014 Jun. 30 [cited 2024 Nov. 21];8(2):92-4. Available from: https://ljmr.ly/index.php/ljmr/article/view/1