Mapping of Bacterial Landscape of Neonatal Septicaemia, Tripoli-Libya

Authors

  • Attiya M. Alatery Department of microbiology and immunology f, faculty of pharmacy, University of Tripoli, Tripoli, Libya. Author
  • Salah B. mohamed Department of microbiology and immunology f, faculty of pharmacy, University of Tripoli, Tripoli, Libya. Author
  • wejdan Allied Department of microbiology and immunology f, faculty of pharmacy, University of Tripoli, Tripoli, Libya. Author
  • shahd sholak Department of microbiology and immunology f, faculty of pharmacy, University of Tripoli, Tripoli, Libya. Author
  • fyrouz F. Algabry Department of microbiology and immunology f, faculty of pharmacy, University of Tripoli, Tripoli, Libya. Author

DOI:

https://doi.org/10.54361/LJMR.19.1.05

Keywords:

Newborn, Septicemia, Bacteria, Gram Negative, EOS, LOS and Libya

Abstract

Purpose: The objective of this study is to investigate the distribution and types of bacteria causing septicemia in newborns at Aljala Hospital in Tripoli, aiming to enhance understanding for better prevention and treatment of neonatal sepsis

Method: This retrospective study gathered data from newborns with sepsis at Aljala Hospital in Tripoli, Libya, from 2014 to 2023, It focused on various factors, including the type of delivery, the causes of sepsis, and the types of microorganisms involved in the infections.

Results The findings reveal a concerning predominance of Gram-negative bacteria, which constitute 63% of the identified pathogens, compared to 37% of Gram-positive bacteria. Notably, Staphylococcus aureus and Escherichia coli emerged as the most prevalent bacterial species associated with neonatal septicemia.

Conclusion:

This research underscores the urgent need for enhanced infection control measures and targeted therapeutic strategies to mitigate the impact of neonatal sepsis in such vulnerable populations.

 

References

Gebrehiwot A, Lakew W, Moges F, Moges B, Anagaw B, Yismaw G, et al. Bacterial profile and drug susceptibility pattern of neonatal sepsis in Gondar University Hospital, Gondar northwest Ethiopia. Der Pharmacia Lettre. 2012;4(6):1811-6.

Wynn JL, Wong HR, Shanley TP, Bizzarro MJ, Saiman L, Polin RA. Time for a neonatal–specific consensus definition for sepsis. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2014;15(6):523.

Medhat H, Khashana A. Incidence of neonatal infection in South Sinai, Egypt. International Journal of Infection. 2017;4(1).

Lawn JE, Blencowe H, Oza S, You D, Lee AC, Waiswa P, et al. Every Newborn: progress, priorities, and potential beyond survival. Lancet. 2014;384(9938):189-205.

King A, Juszczak E. U. Kingdom et al.,“Treatment of neonatal sepsis with intravenous immune globulin,”. The New England Journal of Medicine. 2011;365(13):1201-11.

El Jadba AEHN, El Yazji MS. Neonatal septicemia in Gaza city hospitals. Pak J Med Sci. 2009;25(2):226-31.

Hannan A, Qamar MU, Usman M, Waheed KAI, Rauf K. Multidrug resistant microorganisms causing neonatal septicemia: In a tertiary care hospital Lahore, Pakistan. Afr J Microbiol Res. 2013;7(19):1896-902.

Bassetti M, Righi E, Carnelutti A, Graziano E, Russo AJEroa-it. Multidrug-resistant Klebsiella pneumoniae: challenges for treatment, prevention and infection control. 2018;16(10):749-61.

Al Bakoush FB, Azab AE, Yahya RAJSARJAMS. Neonatal Sepsis: Insight into Incidence, Classification, Risk Factors, Causative Organisms, Pathophysiology, Prognosis, Clinical Manifestations, Complications, Systemic Examination, and Treatment. 2023;5(6):136-57.

Dinagde TO, Simbo TS, Gebaba EMJEJoHD. Bacterial Neonatal Sepsis and Associated Risk Factors among Neonates: The Case of Adama Hospital Medical College. 2023;37(1).

Strunk T, Molloy EJ, Mishra A, Bhutta ZAJTL. Neonatal bacterial sepsis. 2024;404(10449):277-93.

Gao K, Fu J, Guan X, Zhu S, Zeng L, Xu X, et al. Incidence, bacterial profiles, and antimicrobial resistance of culture-proven neonatal sepsis in south China. 2019:3797-805.

Geleta D, Abebe G, Tilahun T, Ahmed H, Workneh N, Beyene GJBID. Prevalence and pathogen profiles of bacteremia in neonates hospitalized for clinical Sepsis in Ethiopia: a systematic review and meta-analysis. 2024;24(1):1424.

Muhammad Z, Ahmed A, Hayat U, Wazir MS, Waqas HJJoAMCA. Neonatal sepsis: causative bacteria and their resistance to antibiotics. 2010;22(4):33-6.

Lakbar I, Einav S, Lalevée N, Martin-Loeches I, Pastene B, Leone MJM. Interactions between gender and sepsis—implications for the future. 2023;11(3):746.

Hafidh Y, Hidayah D, Sunyataningkamto SJPI. Factors affecting mortality of neonatal sepsis in Moewardi Hospital, Surakarta. 2007;47(2):74-7.

17. SOMAN M, GREEN B, DALING JJAjoe. Risk factors for early neonatal sepsis. 1985;121(5):712-9.

Rafi MA, Miah MMZ, Wadood MA, Hossain MGJPo. Risk factors and etiology of neonatal sepsis after hospital delivery: A case-control study in a tertiary care hospital of Rajshahi, Bangladesh. 2020;15(11):e0242275.

Sands K, Spiller OB, Thomson K, Portal EA, Iregbu KC, Walsh TRJI, et al. Early-onset neonatal sepsis in low-and middle-income countries: current challenges and future opportunities. 2022:933-46.

Migamba SM, Kisaakye E, Komakech A, Nakanwagi M, Nakamya P, Mutumba R, et al. Trends and spatial distribution of neonatal sepsis, Uganda, 2016–2020. 2023;23(1):770.

Zelellw DA, Dessie G, Worku Mengesha E, Balew Shiferaw M, Mela Merhaba M, Emishaw SJBri. A Systemic Review and Meta‐analysis of the Leading Pathogens Causing Neonatal Sepsis in Developing Countries. 2021;2021(1):6626983.

Jajoo M, Kapoor K, Garg L, Manchanda V, Mittal SJJoCN. To study the incidence and risk factors of early onset neonatal sepsis in an out born neonatal intensive care unit of India. 2015;4(2):91-5.

Milton R, Gillespie D, Dyer C, Taiyari K, Carvalho MJ, Thomson K, et al. Neonatal sepsis and mortality in low-income and middle-income countries from a facility-based birth cohort: an international multisite prospective observational study. 2022;10(5):e661-e72.

Downloads

Published

01-01-2025

Issue

Section

Articles

How to Cite

1.
Alatery A, mohamed S, Allied wejdan, sholak shahd, Algabry fyrouz. Mapping of Bacterial Landscape of Neonatal Septicaemia, Tripoli-Libya. LJMR [Internet]. 2025 Jan. 1 [cited 2025 Feb. 5];19(1):24-9. Available from: http://ljmr.ly/index.php/ljmr/article/view/305