Assessing the impact of long-term omeprazole therapy: Across-sectional analysis of adverse effects"

Nasrien Elfarrah; Abdulhakim Naffati; Hajer Ali; Amnna  Abudalal; Hanan   Thwer; Asmaa Absheenah

doi:10.26719/LJM19.1.2

Authors

Nasrien Elfarrah Libyan medical research center Author
Abdulhakim Naffati Libyan medical research center Author
Hajer.Taher Ali Libyan medical research center Author
Amnna Salem Abudalal Libyan medical research center Author
Hanan Alhadi Thwer Faculty of Medical Technology, University of zawia Author
Asmaa Absheenah Author

DOI:

https://doi.org/10.26719/LJM19.1.2

Keywords:

omeprazole, long term use, adverse effect

Abstract

Background: Omeprazole is one of the most commonly prescribed of protein pump inhibitors (PPIs) drugs which used widely to manage many gastric acid-related conditions such as gastro esophageal disease, gastritis, esophagitis, Barrett’s esophagus, Zollinger-Ellison syndrome, peptic ulcer disease, nonsteroidal anti-inflammatory drug-associated ulcers, and Helicobacter pylori eradication, globally

.Aim of study: to evaluate the adverse effects associated with the long-term use of proton pump inhibitors drug( omeprazole).

Methodology : a descriptive study for 304 participants were conducted to fill a questionnaire to evaluate the adverse effect of long term use of omeprazole, data were analyzed statistically by SPSSV21.

Results: positive correlation between UTI infection and long term use of omeprazole . 66%of people who used omeprazole have deficiency in vitamin D, other side effects are showed in long term use of omeprazole as gastritis , confusion, .

Conclusion: because the improper use of omeprazole as a save drug more studies need to evaluate the risk of long term use of omeprazole.

References

Shin JM, Sachs G. Pharmacology of proton pump inhibitors. Curr Gastroenterol Rep. 2008;10(6):528-34.

Shin JM, Munson K, Vagin O, Sachs G. The gastric HK-ATPase: structure, function, and inhibition. Pflügers Archiv-European J Physiol. 2009;457(3):609-22.

Kinoshita Y, Ishimura N, Ishihara S. Advantages and disadvantages of long-term proton pump inhibitor use. J Neurogastroenterol Motility. 2018;24(2):182.

Galdo JA. Long-term consequences of chronic proton pump inhibitor use. US Pharm. 2013;38(12):38-42.

Sharma N, Chau WY, Dobruskin L. Effect of long-term proton pump inhibitor therapy on hemoglobin and serum iron levels after sleeve gastrectomy. Surgery for Obesity Related Diseases. 2019;15(10):1682-9.

Shikata T, Sasaki N, Ueda M, et al. Use of proton pump inhibitors is associated with anemia in cardiovascular outpatients. Circulation. 2014:CJ-14-0582.

Kaczmarczyk O, Przybylska-Feluś M, Piątek- Guziewicz A, et al. Effect of long-term proton pump inhibitor therapy on complete blood count parameters and selected trace elements: a pilot study. Polish Archives of Internal Medicine. 2020;130(3).

Sarzynski E, Puttarajappa C, Xie Y, Grover M, Laird- Fick H. Association between proton pump inhibitor use and anemia: a retrospective cohort study. Digestive Diseases Sciences. 2011;56(8):2349-53.

Imai R, Higuchi T, Morimoto M, Koyamada R, Okada S. Iron deficiency anemia due to the long-term use of a proton pump inhibitor. Internal Medicine.

;57(6):899-901.

Krieg L, Milstein O, Krebs P, Xia Y, Beutler B, Du X. Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice. Blood. 2011;118(24):6418-25.

McColl KE. Effect of proton pump inhibitors on vitamins and iron. Am J Gastroenterol. 2009;104:S5-S9.

Alkhalaylah AA, Hayajneh MM, Hijazeen SI, Alqhewii TA, Haddad ER, Alkhatib AJ. Study the overprescription of proton pump inhibitors and their relation with recurrent community aquired infections in outpatient refilled prescriptions of chronic diseases patients. Eur Sci J. 2016;12(6).

Ribeiro RHT, Ribeiro FA, Silva RPM, Bortolini MJS, Garrote-Filho MdS, Penha-Silva N. Depression, hematologic parameters, and blood levels of vitamin B12 in patients with laryngopharyngeal reflux under use of proton pump inhibitors. Clin Med Insights: Ear, Nose and Throat. 2019;12:1-7.

Freedberg DE, Kim LS, Yang YX. The risks and benefits of long-term use of proton pump inhibitors: expert review and best practice advice from the American Gastroenterological Association. Gastroenterology . 2017;152:706–715 .

Gingold AR, Narasimhan G, Augello S, Clain DJ. The prevalence of proton pump inhibitor use in hospitalized patients. Am J Gastroenterol . 2004;99:S35–S36

Vatcharavongvan P, Puttawanchai V. Elderly patients in primary care are still at risks of receiving potentially inappropriate medications. J Prim Care Community Health 2021;12. doi: 10.1177/21501327211035088.