Uncontrolled Diabetes is a Risk Factor for Chronic Kidney Disease in Tsawa City Southern Libya

Ail  Alahrash; Osama Almjdoub; Asmahan Abukhdir; Abdusalam  Abdull; Hajer Rashed; Kaled  Aburas; Nasrin Elfarrah; Salah Bahron

doi:10.26719/LJMR.18.2.14

Authors

Ail Abd Alahrash . Libyan Medical Research Center , Zawia, Libya. and Faculty of Medicine, University of Zawia, Zawia, Libya. Author
Osama H .Almjdoub Libyan Medical Research Center , Zawia, Libya. Author
Asmahan Abukhdir Libyan Medical Research Center , Zawia, Libya. Author
Abdusalam M. Abdull Faculty of Medicine, University of Zawia, Zawia, Libya. Author
Hajer Rashed Libyan Medical Research Center , Zawia, Libya. Author
Kaled Aburas Libyan Medical Research Center , Zawia, Libya Author
Nasrin Elfarrah Libyan Medical Research Center , Zawia, Libya Author
Salah Bahron Libyan Medical Research Center , Zawia, Libya. Author

DOI:

https://doi.org/10.26719/LJMR.18.2.14

Keywords:

Diabetes, chronic kidney disease, Tsawa, Libya

Abstract

Purpose: Long-term uncontrolled diabetes can cause a deterioration in the kidney function. The diabetes is the most frequent cause of chronic kidney disease (CKD) in most countries. In previous study in Libya as a cause of CKD in (49%) of study sample. for this reason, we investigated and collected data from the Tsawa city southern Libya to determine the relationship between uncontrolled diabetes and the CKD. Methods: In this cross-sectional study, data was collected from 303 adults visiting Tsawa Hospital from July 2023 to august 2023. Biochemical parameters, including random blood sugar, HA1C, kidney function tests (urea, creatinine) and urine. Statistical analysis using SPSS version 21 program to calculate correlation between analysis values. Results: There is a significant correlation between blood glucose levels and kidney dysfunction was observed (p < 0.05), (p< 0.01) The study revealed that 31% of the 303 participants examined had high random blood sugar levels. Among these cases, 57% (**p< 0.01) had elevated urea levels. 71 % of the cases showed elevated HbA1c levels which suggests that individuals with poorly controlled blood sugar over time. The study found that 8% diabetic patients (*p < 0.05) had elevated creatinine levels. 53% of patients (**p< 0.01) showing proteinuria which is a crucial indicator of kidney damage, and its presence in over half of the diabetic patients in this study indicates that a significant proportion of individuals with diabetes are at risk of developing more severe kidney damage. Conclusions: Uncontrolled long standing Diabetes considered as a risk factor for Chronic Kidney Disease, so, comprehensive diabetes management and regular monitoring of the kidney functions in diabetics are vital components to prevent or delay the onset of chronic kidney disease.

References

Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047–53. doi: 10.2337/diacare.27.5.1047. [DOI] [PubMed] [Google Scholar.

Omran Bakoush 1 and Targ Elgzyri, Do we have a diabetes epidemic in Libya? Libyan J Med, December 2006, AOP: 061016,

Kalluri, R., & Nair, V. (2016). Diabetes and urinary tract infections: Pathophysiology and clinical management. American Journal of Kidney Diseases, 68(6), 909-916.

Elmukhtar M Habas , Jamila Elamouri and Amnna A Rayani , Chronic Kidney Disease in Libya, Cross-sectional Single Center Study, Epidemiology (Sunnyvale) 2016, 6:5

DOI: 10.4172/2161-1165.1000264

Van Der Meer, E. J., et al. (2017). "The relationship between diabetes and chronic kidney disease in a cohort of patients with type 2 diabetes." Diabetologia, 60(8), 1417-1424.

Zhang L., Zhao M. H., Zuo L., Wang Y., Yu F., Zhang H., Wang H., Chen R., Chu H., Deng X., Gan L., Gao B., Jiang Y., Liu L., Long J., Shi Y., Su Z., Sun X., Tang W., Wang F., Wang H. Y., Wang J., Wang S., Yang C., Zhang D., Zhao X., Zheng L., and Zhou Z., China kidney disease network (CK-NET) 2016 annual data report, Kidney International Supplements. (2020) 10, no. 2, e97–e185, https://doi.org/10.1016/j.kisu.2020.09.001, 33304640.].

Xiaohong Zhang, Yuan Fang, Zhenhuan Zou, Pianpian Hong, Yongjie Zhuo, Yanfang Xu, Jianxin Wan Risk Factors for Progression of CKD with and without Diabetes First published: 22 August 2022 https://doi.org/10.1155/2022/961306

Ali Abd. Alahrash ,Osams H .Almjdoub, ,Nasrin Elfarrah ,Kaled Aburas ,Asmahan Abukhdir ,Abdusalam M.Abdull ,Salah Bahroen , increase the chronic kidney disease (CKD) in Wadi Ataba City southern Libya. Libyan Journal of Medical Research (LJMR) eISSN:2413-6096.

Vejakama P., Ingsathit A., Attia J., and Thakkinstian A., Epidemiological study of chronic kidney disease progression, Medicine. (2015) 94, no. 4, article e475, https://doi.org/10.1097/MD.0000000000000475, 2-s2.0-84938069004, 25634196.

Evans M., Grams M. E., Sang Y., Astor B. C., Blankestijn P. J., Brunskill N. J., Collins J. F., Kalra P. A., Kovesdy C. P., Levin A., Mark P. B., Moranne O., Rao P., Rios P. G., Schneider M. P., Shalev V., Zhang H., Chang A. R., Gansevoort R. T., Matsushita K., Zhang L., Eckardt K. U., Hemmelgarn B., and Wheeler D. C., Risk factors for prognosis in patients with severely decreased GFR, Kidney International Reports. (2018) 3, no. 3, 625–637, https://doi.org/10.1016/j.ekir.2018.01.002, 2-s2.0-85044849650, 29854970.

Chang H. L., Wu C. C., Lee S. P., Chen Y. K., Su W., and Su S. L., A predictive model for progression of CKD, Medicine. (2019) 98, no. 26, article e16186, https://doi.org/10.1097/MD.0000000000016186,2-s2.0-85069261703, 31261555.