Prevalence of Immunotherapy Practices in a certain region in Libya
DOI:
https://doi.org/10.54361/LJMR.20.1.07Keywords:
Cancer, Immunotherapy, Chemotherapy, and Radiation, Tripoli Teaching Medical Hospital, Sabratha Oncology Hospital, Al-Yasmeen Center for Radiotherapy, Misurata Oncology Hospital, LibyaAbstract
Background: In recent years, immunotherapy has emerged as one of the most promising approaches in cancer treatment. This therapeutic strategy enhances the body’s natural immune system to recognize and eliminate cancer cells. Unlike traditional chemotherapy and radiation therapy, immunotherapy aims to target cancer tumors while minimizing damage to healthy tissues. Aim of the Study: The study aimed to identify and evaluate key strategies that enhance the immune system’s ability to combat cancer. These strategies include the use of immune-stimulatory factors and modifications to chemotherapy protocols that support immune function. Materials and Methods: This study included 30 cancer patients recruited from several hospitals in Libya. Fifteen cases were obtained from Tripoli Teaching Medical Hospital, nine from Sabratha Oncology Hospital, five from Al-Yasmeen Center for Radiotherapy, and one case from Misurata Oncology Hospital. Data collected included age, gender, presence of chronic diseases, cancer type, and disease stage. The study was conducted over a three-month period from October to December 2023.Results: The results showed that 46.7% of the participating patients received immunotherapy, highlighting the critical role of. The immune system is a primary defense mechanism against cancer. The immune system targets cancer cells through specialized immune cells such as T lymphocytes and natural killer cells, as well as through the secretion of immune-mediated compounds that attack tumors. Conclusion: The immune system represents a fundamental barrier against cancer development and progression. Understanding immune mechanisms and the factors influencing immune responses is essential for developing more effective cancer treatment strategies, particularly in Libya.
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References
1. Arrowsmith J. Trial watch: phase III and submission failures: 2007-2010. Nat Rev Drug Discov. 2011 Feb;10(2):87.
2. Bourke JM, O'Sullivan M, Khattak MA. Management of adverse events related to new cancer immunotherapy (immune checkpoint inhibitors). Med J Aust. 2016 Nov 7;205(9):418-24.
3. Chughtai B, Venkatraman G, Gressler L, Elterman D, Bhojani N. The role of manufacturer and user facility database in evaluating BPH and prostate cancer procedures. World J Urol. 2025;44(1):24.
4. Demko S, Summers J, Keegan P, Pazdur R. FDA drug approval summary: alemtuzumab as single-agent treatment for B-cell chronic lymphocytic leukemia. Oncologist. 2008;13(2):167-74.
5. Ebata Y, Sakaguchi Y, Tsuda Y, Nambara S, Kudou K, Kusumoto E, et al. A case of undifferentiated pleomorphic sarcoma in esophagus after multiple cancer treatments of surgery and chemoradiotherapy. Surg Case Rep. 2022 Oct 8;8(1):205.
6. Espinoza-Sánchez NA, Götte M. Role of cell surface proteoglycans in cancer immunotherapy. Semin Cancer Biol. 2020 May;62:48-67.
7. Gupta SL, Basu S, Soni V, Jaiswal RK. Immunotherapy: an alternative promising therapeutic approach against cancers. Mol Biol Rep. 2022 Oct;49(10):9903-13.
8. Johnston BJ, Novales ET. Clinical effect of Coley's toxin. II. A seven-year study. Cancer Chemother Rep. 1962 Mar;21:43-68.
9. Kao C, Charmsaz S, Tsai HL, Aziz K, Shu DH, Munjal K, et al. Age-related divergence of circulating immune responses in patients with solid tumors treated with immune checkpoint inhibitors. Nat Commun. 2025 Apr 11;16(1):3531.
10. Kienle GS. Fever in Cancer Treatment: Coley's Therapy and Epidemiologic Observations. Glob Adv Health Med. 2012 Mar;1(1):92-100.
11. Khalil DN, Smith EL, Brentjens RJ, Wolchok JD. The future of cancer treatment: immunomodulation, CARs and combination immunotherapy. Nat Rev Clin Oncol. 2016 May;13(5):273-90.
12. Konieczny M, Sawicka J, Gąska I, Kaczmar E, Pasek M, Kiedik A, et al. Anxiety and Depression in Breast Cancer Patients Before and After Chemotherapy: A Pre-Post Study Without a Control Group. J Clin Med. 2025 Nov;14(22):8105.
13. Korneev KV, Atretkhany KN, Drutskaya MS, Grivennikov SI, Kuprash DV, Nedospasov SA. TLR-signaling and proinflammatory cytokines as drivers of tumorigenesis. Cytokine. 2017 Jan;89:127-135.
14. Kucerova P, Cervinkova M. Spontaneous regression of tumour and the role of microbial infection--possibilities for cancer treatment. Anticancer Drugs. 2016 Apr;27(4):269-77.
15. McCarthy EF. The toxins of William B. Coley and the treatment of bone and soft-tissue sarcomas. Iowa Orthop J. 2006;26:154-8.
16. Mukherjee AG, Wanjari UR, Namachivayam A, Murali R. Role of Immune Cells and Receptors in Cancer Treatment: An Immunotherapeutic Approach. Vaccines (Basel). 2022 Sep 7;10(9):1493.
17. Oberneder R, Weckermann D, Ebner B, Quadt C, Kirchinger P, Raum T, et al. A phase I study with adecatumumab, a human antibody directed against epithelial cell adhesion molecule, in hormone refractory prostate cancer patients. Eur J Cancer. 2006 Oct;42(15):2530-8.
18. Prang N, Preithner S, Brischwein K, Göster P, Wöppel A, Müller J, et al. Cellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines. Br J Cancer. 2005 Jan 31;92(2):342-9.
19. Shiravand Y, Khodadadi F, Kashani SMA, Hosseini-Fard SR, Hosseini S, Sadeghirad H, et al. Immune Checkpoint Inhibitors in Cancer Therapy. Curr Oncol. 2022 Apr 24;29(5):3044-60.
20. Spain L, Diem S, Larkin J. Management of toxicities of immune checkpoint inhibitors. Cancer Treat Rev. 2016 Feb;44:51-60.
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